{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:54:21Z","timestamp":1791172461659,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Rhodococcus equi<\/jats:italic>\n                      \u2013specific hyperimmune plasma (Re\u2010HIP) is routinely administered to neonatal foals to help prevent rhodococcal pneumonia. In addition to pathogen\u2010specific immunoglobulins, frozen plasma products (FPPs) contain electrolytes that may exceed concentrations found in neonatal foal plasma. Because FPPs are also used to treat failure of passive transfer and sepsis, understanding their effects on neonate homeostasis is crucial. This study evaluated the effects of administration of Re\u2010HIP on the serum concentrations of Na\n                      <jats:sup>+<\/jats:sup>\n                      , Cl\n                      <jats:sup>\u2212<\/jats:sup>\n                      , K\n                      <jats:sup>+<\/jats:sup>\n                      , albumin, and globulin of healthy neonatal foals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Findings<\/jats:title>\n                    <jats:p>\n                      The concentration of Na\n                      <jats:sup>+<\/jats:sup>\n                      was high in Re\u2010HIP when compared with normal plasma values. Administration of Re\u2010HIP resulted in an increase in serum Na\n                      <jats:sup>+<\/jats:sup>\n                      , Cl\n                      <jats:sup>\u2212<\/jats:sup>\n                      , albumin, and globulin concentrations in neonatal foals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>The serum electrolyte changes seen after Re\u2010HIP administration were likely of no clinical significance in healthy foals. However, the administration of hypernatremic plasma to septic or dehydrated foals could exacerbate electrolyte imbalances. These results suggest that caution and close monitoring are warranted when administering FPPs to critically ill foals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vec.70131","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:40:27Z","timestamp":1784029227000},"page":"571-574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Electrolyte Changes in Foals Receiving\n                    <i>Rhodococcus equi<\/i>\n                    \u2013Specific Hyperimmune Plasma"],"prefix":"10.1111","volume":"36","author":[{"given":"Diego S.","family":"Larriva","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine Washington State University  Pullman Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis G.","family":"Arroyo","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Ontario Veterinary College University of Guelph  Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon N.","family":"Lillie","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Ontario Veterinary College University of Guelph  Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macarena G.","family":"Sanz","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine Washington State University  Pullman Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.13127"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.102594"},{"issue":"2","key":"e_1_2_12_4_1","first-page":"193","article-title":"Plasma Transfusions in Horses With Typhlocolitis\/Colitis","volume":"60","author":"Arroyo L. G.","year":"2019","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939\u20101676.2008.0254.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.23.08.0180"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15597"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973\u20106247.95049"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/avj.12749"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.103095"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255\u2010024\u201004305\u20100"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jevs.2011.08.015"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119617228"}],"container-title":["Journal of Veterinary Emergency and Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.70131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vec.70131","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vec.70131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:29:35Z","timestamp":1791170975000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vec.70131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/vec.70131"],"URL":"https:\/\/doi.org\/10.1111\/vec.70131","archive":["Portico"],"relation":{},"ISSN":["1479-3261","1476-4431"],"issn-type":[{"value":"1479-3261","type":"print"},{"value":"1476-4431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-03-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}