{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:54:19Z","timestamp":1791172459759,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":37,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe systemic protothecosis as a novel differential for hypoadrenocorticism\u2010like clinicopathologic findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Summary<\/jats:title>\n                    <jats:p>\n                      A 3\u2010year\u2010old neutered female Labrador Retriever was evaluated for an episode of acute lethargy, hyporexia, and ataxia. The dog had a prior history of chronic gastrointestinal signs with no underlying cause determined. On presentation, the dog had several clinicopathologic changes similar to those seen in cases of hypoadrenocorticism, most notably a severe hyperkalemia and hyponatremia, with a sodium\u2010to\u2010potassium ratio of &lt;14:1. A diagnosis of\n                      <jats:italic>Prototheca bovis<\/jats:italic>\n                      infection was made based on the histopathology of endoscopic biopsies and confirmatory polymerase chain reaction. The dog initially had a positive response to treatment with oral antifungals but was later euthanized due to the progression of ophthalmologic and neurologic signs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>New or Unique Information Provided<\/jats:title>\n                    <jats:p>Based on a literature search and to the authors\u2019 knowledge, this is the first time canine protothecosis has been associated with severe hyperkalemia and one of only a few reports of gastrointestinal disease resulting in severe hyperkalemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vec.70136","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T09:05:51Z","timestamp":1786093551000},"page":"557-566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Severe Gastrointestinal Disease in a Dog Presenting With Hypoadrenocorticism\u2010Like Electrolyte Derangements Due to Protothecosis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8359-0554","authenticated-orcid":false,"given":"Rachel G.","family":"Angles","sequence":"first","affiliation":[{"name":"Massachusetts Society for the Prevention of Cruelty to Animals, Angell West  Waltham Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney M.","family":"Peck","sequence":"additional","affiliation":[{"name":"Massachusetts Society for the Prevention of Cruelty to Animals, Angell West  Waltham Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Mouser","sequence":"additional","affiliation":[{"name":"Angell Animal Medical Center Massachusetts Society for the Prevention of Cruelty to Animals  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patty","family":"Ewing","sequence":"additional","affiliation":[{"name":"Angell Animal Medical Center Massachusetts Society for the Prevention of Cruelty to Animals  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Ackley","sequence":"additional","affiliation":[{"name":"Massachusetts Society for the Prevention of Cruelty to Animals, Angell West  Waltham Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"20","article-title":"GI Intervention: Approach to Diagnosis and Therapy of the Patient With Acute Diarrhea","author":"Armstrong P. 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