{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T12:43:58Z","timestamp":1792327438446,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Vet Emergen Crit Care"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To report serum baclofen concentrations before, during, and after in\u2010series carbon hemoperfusion (cHP) and hemodialysis (HD) in four dogs with severe baclofen toxicosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Series Summary<\/jats:title>\n                    <jats:p>This series involves four dogs with serum samples collected before, during, and after in\u2010series cHP\/HD. The extraction ratio (ER, %) of cHP and HD, half\u2010life during cHP\/HD, and total extracorporeal elimination constant were calculated. Posttreatment samples were collected to determine endogenous half\u2010life and intrinsic elimination constant. Two dogs received both cHP\/HD and mechanical ventilation, while the other two received cHP\/HD alone. The range of ingested dosages was 4\u201324\u00a0mg\/kg. The median time from suspected ingestion to cHP\/HD initiation was 7\u00a0h (range: 5\u201315\u00a0h). Extracorporeal therapy was performed using an intermittent hemodialysis platform in two cases and a continuous renal replacement therapy platform in two cases. The median duration of cHP\/HD was 3\u00a0h (range: 2.2\u20134\u00a0h), with a median total blood volume processed of 1.3 L\/kg (range: 1\u20131.5 L\/kg), equating to 15 times (range: 12\u201318.2 times) the estimated blood volume (80\u00a0mL\/kg) in dogs. Serum baclofen concentration was reduced during cHP\/HD by a median 69% (range: 46%\u201380%). The median ER for cHP was 61% (range: 60%\u201381%) and for HD was 4% (range: \u22120.5% to 11.5%). The calculated half\u2010life during cHP\/HD was 1.9\u00a0h (range: 1.1\u20132.5\u00a0h), compared with 5.8\u00a0h (range: 3.1\u201313.6\u00a0h) after cHP\/HD. The median extracorporeal elimination constant was 0.34 (range: 0.08\u20130.37), which was 2.8 times faster than the intrinsic elimination constant of 0.12 (range: 0.05\u20130.23).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>New or Unique Information Provided<\/jats:title>\n                    <jats:p>In\u2010series cHP\/HD reduced serum baclofen concentrations in this small series of dogs, highlighting its potential role in the treatment of severe baclofen intoxication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vec.70160","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:08:30Z","timestamp":1788415710000},"page":"673-681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Baclofen Concentrations in Four Dogs With Baclofen Toxicosis Treated With In\u2010Series Carbon Hemoperfusion and Hemodialysis"],"prefix":"10.1111","volume":"36","author":[{"given":"Amanda","family":"Spillane","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwoong","family":"Her","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine The Ohio State University  Columbus Ohio USA"},{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahvid","family":"Etedali","sequence":"additional","affiliation":[{"name":"Animal Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Finstad","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Langston","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12221"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/PRM\u20102011\u20100160"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00558228"},{"key":"e_1_2_14_5_1","first-page":"142","volume-title":"Blackwell's Five\u2011Minute Veterinary Consult Clinical Companion: Small Animal Toxicology","author":"Quandt J.","year":"2011"},{"key":"e_1_2_14_6_1","first-page":"406","article-title":"Baclofen Overdose in Dogs","volume":"99","author":"Wismer T.","year":"2004","journal-title":"Veterinarni Medicina"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.241.8.1059"},{"key":"e_1_2_14_8_1","unstructured":"\u201cPubChem Compound Summary for CID 2284 Baclofen \u201dNational Center for Biotechnology Information accessed April 19 2023 https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Baclofen."},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20104431.2008.00310.x"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/20551169211033770"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.1032"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20104431.2006.00210.x"},{"key":"e_1_2_14_13_1","volume-title":"Prescribing Hemodialysis: A Guide to Urea Modeling","author":"Depner T. 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