{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T11:54:48Z","timestamp":1769082888188,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T00:00:00Z","timestamp":1355097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective\u2002<\/jats:bold>To develop fast and reliable testing routines for diagnosing retina and optic nerve diseases in canine cataract patients based on chromatic properties of the pupillary light reflex response.<\/jats:p><jats:p><jats:bold>Procedures\u2002<\/jats:bold>Seventy\u2010seven canine patients with a history of cataract and decreased vision (43 patients with cataracts and no evidence of retina or optic nerve disease, 21 patients with cataracts and retinal degeneration [RD], 13 patients with cataracts and retinal detachment [RDT]), 11 canine patients with optic neuritis (ON) and 23 healthy dogs were examined using chromatic pupillary light reflex (cPLR) analysis with red and blue light and electroretinography.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold>Electroretinography analysis showed statistically significant deficits in a\u2010 and b\u2010wave amplitudes in dogs with cataracts and RD, or cataracts and RDT, when compared to dogs with cataracts without evidence of retinal abnormalities. Evaluation of b\u2010wave amplitudes showed that presence of 78.5\u2010\u03bcV (or lower) amplitudes had high sensitivity of 100% (95% CI: 87.2\u2013100%) and high specificity of 96.7% (95% CI: 88.4\u2013100%) in RD and RDT. Evaluation of cPLR responses using red light showed that presence of the pupil end constriction diameter of 5.5\u2003mm (or higher) had moderately high sensitivity of 76.5% (95% CI: 50.1\u201393.2%) and high specificity of 100% (95% CI: 91.2\u2013100%) in detecting RD and RDT. Optic neuritis patients had absent cPLR responses, regardless of the visual status.<\/jats:p><jats:p><jats:bold>Conclusions and Clinical Relevance\u2002<\/jats:bold>Chromatic evaluation of the pupillary light reflex is a rapid and accurate test for diagnosing retina and optic nerve diseases in canine patients.<\/jats:p>","DOI":"10.1111\/vop.12003","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T12:34:16Z","timestamp":1355229256000},"page":"329-340","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Rapid diagnosis of retina and optic nerve abnormalities in canine patients with and without cataracts using chromatic pupil light reflex testing"],"prefix":"10.1111","volume":"16","author":[{"given":"Sinisa D.","family":"Grozdanic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helga","family":"Kecova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Lazic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,10]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2009.00697.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2007.00559.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2006.00490.x"},{"key":"e_1_2_7_5_2","first-page":"295","article-title":"[Weak vision and blindness in the dog\u2010\u2010a retrospective study]","volume":"107","author":"Granitz U","year":"1994","journal-title":"Berliner und Munchener Tierarztliche Wochenschrift"},{"key":"e_1_2_7_6_2","doi-asserted-by":"crossref","first-page":"838","DOI":"10.2460\/javma.1993.203.06.0838","article-title":"Ultrasonographic abnormalities in the eyes of dogs with cataracts: 147 cases (1986\u20131992)","volume":"203","author":"Van der Woerdt A","year":"1993","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_7_7_2","first-page":"770","article-title":"The pupillary light reflex. 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