{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:49:15Z","timestamp":1785883755826,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T00:00:00Z","timestamp":1355097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Topical latanoprost 0.005% is commonly used in dogs with primary angle closure glaucoma (<jats:styled-content style=\"fixed-case\">PACG<\/jats:styled-content>), and marked miosis has been reported in the literature. To further explore the effect of topical latanoprost on anterior segment anatomy, we performed iridocorneal angle biometrics in normal beagle dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010five normal female beagle dogs were assessed using anterior segment optical coherence tomography (<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>). One eye of each dog was scanned with the<jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>in the superotemporal quadrant. One drop of latanoprost 0.005% was applied topically, and the<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>scan was repeated 30\u00a0min later. Images were imported into ImageJ, and pupil diameter, anterior chamber angle, angle opening distance, angle recess area (ARA), anterior chamber hemifield, and anterior chamber depth were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A single drop of latanoprost resulted in marked miosis, anterior bowing of the peripheral iris, narrowing of the iridocorneal angle, and shallowing of the anterior chamber. The anterior segment parameters demonstrated a significant reduction (<jats:italic>P<\/jats:italic>\u2010value\u00a0\u2264\u00a00.001) from baseline following latanoprost with the exception of the<jats:styled-content style=\"fixed-case\">ARA<\/jats:styled-content>(<jats:italic>P<\/jats:italic>\u00a0=\u00a00.07).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Latanoprost significantly decreases pupil diameter and narrows the iridocorneal angle in normal female beagle dogs. Therefore, the utility of latanoprost as a prophylactic treatment for<jats:styled-content style=\"fixed-case\">PACG<\/jats:styled-content>in fellow eyes may be limited. Studies using quantitative iridocorneal angle measurements in goniodysgenic dogs are warranted to understand the changes in iridocorneal angle morphology that occur in<jats:styled-content style=\"fixed-case\">PACG<\/jats:styled-content>in response to topical application of latanoprost.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12011","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T12:29:32Z","timestamp":1355228972000},"page":"370-376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The effect of topical latanoprost on anterior segment anatomic relationships in normal dogs"],"prefix":"10.1111","volume":"16","author":[{"given":"Susan","family":"Tsai","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Colorado State University Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Almazan","sequence":"additional","affiliation":[{"name":"Allergan, Inc. Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Allergan, Inc. Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajiang","family":"Li","sequence":"additional","affiliation":[{"name":"Allergan, Inc. Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Conforti","sequence":"additional","affiliation":[{"name":"Allergan, Inc. Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Burke","sequence":"additional","affiliation":[{"name":"Allergan, Inc. Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Miller","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine University of Wisconsin\u2010Madison Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Allergan, Inc. 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