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A prospective pilot study was conducted to demonstrate proof of principle of this novel method for the treatment of melting corneal ulcers in dogs and cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>After obtaining owner consent,<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>was performed in three cats and three dogs with corneal melting, which either affected the entire corneal surface or was resistant to conventional antibiotic and anticollagenolytic therapy, and affected parts or all of the corneal surface. Medical therapy was continued in all patients. The available follow\u2010up ranged from 2 to 22.5\u00a0months and involved slit\u2010lamp examination, fluorescein staining, and photographic documentation during all rechecks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Surgical stabilization of the cornea was not necessary in any case, because progression of corneal melting was arrested in all cases within 1\u201320\u00a0days of<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>treatment. Corneal re\u2010epithelization occurred within 7\u201340\u00a0days in all eyes. At 40\u00a0days after<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>, all eyes presented a quiescent corneal state without signs of active inflammation and with beginning scar formation. The complications observed in three of the six animals included a corneal sequestrum, superficial corneal stromal pigmentation, and bullous keratopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study shows the feasibility of<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>to treat progressive corneal melting in veterinary patients.<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>may represent a cost\u2010efficient and safe alternative therapy in the treatment for corneal melting in veterinary ophthalmology. More investigations comparing the effectivity and complication rate of<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>to those of standard medical treatment are necessary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12027","type":"journal-article","created":{"date-parts":[[2013,1,29]],"date-time":"2013-01-29T12:17:24Z","timestamp":1359461844000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Corneal collagen cross\u2010linking (<scp>CXL<\/scp>) for the treatment of melting keratitis in cats and dogs: a pilot study"],"prefix":"10.1111","volume":"17","author":[{"given":"Bernhard M.","family":"Spiess","sequence":"first","affiliation":[{"name":"Equine Department Vetsuisse Faculty University of Zurich Winterthurerstrasse 260, CH\u20108057 Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon 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