{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:48:56Z","timestamp":1773449336384,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T00:00:00Z","timestamp":1369180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate qualitative and quantitative differences in the structure of the posterior segment of the eye in 1\u2010day post\u2010hatch and 12\u2010month\u2010old retinal dysplasia and degeneration (rdd) and wild\u2010type chickens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal studied<\/jats:title><jats:p>Retinal dysplasia and degeneration and wild\u2010type chickens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Using a commercially available spectral domain optical coherence tomography (<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) system, 15\u00b0 horizontal line scans were performed in both eyes of 24 live birds. Qualitative differences in retinal lamination and choroidal structure were investigated, and retinal and choroidal thickness were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Progressive retinal thinning with loss of outer retinal lamination and changes in the appearance of the choroid were seen in the rdd birds. Mean total retinal thickness was 202\u00a0\u03bcm (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 7.8) and 251\u00a0\u03bcm (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 8.8) in the rdd and wild\u2010type chicks and 154\u00a0\u03bcm (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 18) and 280\u00a0\u03bcm (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 10.8) in the adult birds. Much of the difference was the result of loss of outer retinal lamination and thickness in the rdd birds. Mean choroidal thickness was 76\u00a0\u03bcm (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 19.6) and 112\u00a0\u03bcm (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 36.9) in the rdd and wild\u2010type chicks and 85\u00a0\u03bcm (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 23.7) and 228\u00a0\u03bcm (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 44.1) in the rdd and wild\u2010type adult birds, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Differences in retinal and choroidal structure and thickness between rdd and wild\u2010type birds were evident on spectral domain <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> imaging at 1\u2010day post\u2010hatch and more marked at 1\u00a0year. Spectral domain <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> may provide a reliable end point for therapeutic intervention in this animal model of inherited retinal degeneration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12051","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T11:59:12Z","timestamp":1369310352000},"page":"113-119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Spectral domain optical coherence tomography imaging of the posterior segment of the eye in the retinal dysplasia and degeneration chicken, an animal model of inherited retinal degeneration"],"prefix":"10.1111","volume":"17","author":[{"given":"Martin","family":"McKibbin","sequence":"first","affiliation":[{"name":"Eye Clinic St. James's University Hospital Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manir","family":"Ali","sequence":"additional","affiliation":[{"name":"Section of Ophthalmology and Neuroscience Leeds Institute of Molecular Medicine University of Leeds Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Inglehearn","sequence":"additional","affiliation":[{"name":"Section of Ophthalmology and Neuroscience Leeds Institute of Molecular Medicine University of Leeds Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Shires","sequence":"additional","affiliation":[{"name":"Section of Pathology and Tumour Biology Leeds Institute of Molecular Medicine University of Leeds Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenny","family":"Boyle","sequence":"additional","affiliation":[{"name":"Heidelberg Engineering Ltd. Hertfordshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul M.","family":"Hocking","sequence":"additional","affiliation":[{"name":"Roslin Institute and Royal School of Veterinary Studies University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012747605-6\/50002-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5633"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.2.001268"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7872"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(83)90171-9"},{"key":"e_1_2_7_7_1","first-page":"164","article-title":"Analysis of the rdd locus in chicken: a model for human retinitis pigmentosa","volume":"30","author":"Burt DW","year":"2003","journal-title":"Molecular Vision"},{"key":"e_1_2_7_8_1","first-page":"2405","article-title":"Relation of optical coherence tomography to microanatomy in normal and rd chickens","volume":"39","author":"Huang Y","year":"1998","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-1313.2011.00827.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2004.01.011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1197"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.9.1329"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1167\/8.1.17"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3724"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-1383"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-010-1437-3"},{"key":"e_1_2_7_17_1","first-page":"444","article-title":"The relationship between retinal pigment epithelium and the choriocapillaris","volume":"103","author":"Henkind P","year":"1983","journal-title":"Transactions of the Ophthalmological Societies of the United Kingdom"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905010106"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2869"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902100210"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8108"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2009.04.029"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8046"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvop.12051","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.12051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:06:51Z","timestamp":1696205211000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.12051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,22]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/vop.12051"],"URL":"https:\/\/doi.org\/10.1111\/vop.12051","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,22]]},"assertion":[{"value":"2013-05-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}