{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:24:15Z","timestamp":1787016255110,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T00:00:00Z","timestamp":1368576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We describe the clinical, histological, and immunohistochemical features of primary intraocular primitive neuroectodermal tumors in eight dogs. Four of eight tumors exhibited histological features similar to human retinoblastomas characterized by Flexner\u2013Wintersteiner rosettes, and fleurettes, and demonstrated variable immunoreactivity for retinal markers opsin, S\u2010antigen (S\u2010Ag) and interphotoreceptor retinoid\u2010binding protein (\n                    <jats:styled-content style=\"fixed-case\">IRBP<\/jats:styled-content>\n                    ). All dogs with tumors displaying histological and immunohistochemical features of retinal differentiation were \u22642\u00a0years of age. All tumors diagnosed as medulloepitheliomas (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a04) did not display histological and immunohistochemical features of retinal differentiation and were present in dogs 7\u00a0years or older. Age of onset, in conjunction with immunohistochemistry for opsin, S\u2010Ag, and\n                    <jats:styled-content style=\"fixed-case\">IRBP<\/jats:styled-content>\n                    , is an important aid in the differentiation of primary, primitive neuroectodermal tumors arising within the canine ciliary body, retina, and optic papilla.\n                  <\/jats:p>","DOI":"10.1111\/vop.12056","type":"journal-article","created":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T00:27:17Z","timestamp":1368664037000},"page":"87-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Primary primitive neuroectodermal tumors of the retina and ciliary body in dogs"],"prefix":"10.1111","volume":"16","author":[{"given":"Daniel P.","family":"Regan","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences Colorado State University Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Dubielzig","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences University of Wisconsin Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline J.","family":"Zeiss","sequence":"additional","affiliation":[{"name":"Section of Comparative Medicine Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Charles","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences Colorado State University Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah S.","family":"Hoy","sequence":"additional","affiliation":[{"name":"Vermont Veterinary Eye Clinic Williston VT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. J.","family":"Ehrhart","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences Colorado State University Fort Collins CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,15]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Veterinary Neuropathology","author":"Summers BA","year":"1995"},{"key":"e_1_2_6_3_1","volume-title":"World Health Organization. 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