{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:05:53Z","timestamp":1783530353334,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,7,5]],"date-time":"2013-07-05T00:00:00Z","timestamp":1372982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate long\u2010term efficacy of antiglaucoma medications with or without combined topical anti\u2010inflammatory treatment in preventing increased intraocular pressure and clinical signs of glaucoma in eyes considered at risk of the development of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis identified 88 canine patients presenting with unilateral acute congestive primary angle\u2010closure glaucoma (<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\u00a0&gt;\u00a025\u00a0mm\u00a0Hg) and gonioscopic findings of pectinate ligament dysplasia and\/or narrow or closed iridocorneal angle in the contralateral nonglaucomatous eye. Patients with histopathologic confirmation of pectinate ligament dysplasia or angle closure in the initial glaucomatous eye receiving prophylactic medical therapy in the contralateral eye were included. Time to medical failure for each antiglaucoma medication and efficacy of the combination therapy were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most commonly affected pure\u2010breds were the<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>merican<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ocker<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>paniel (20.4%) and<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>asset<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ound (11.36%). The patients receiving demecarium bromide 0.125% had the longest estimated median time to medical failure at 330.0\u00a0days, followed by latanoprost 0.005%, dorzolamide hydrochloride 2.0%, and demecarium bromide 0.25% at 284.0\u00a0days, 272.5\u00a0days, and 143.0\u00a0days, respectively. The estimated median time to medical failure for patients receiving topical antiglaucoma and anti\u2010inflammatory medication was 324.0\u00a0days versus 195.0\u00a0days in patients receiving antiglaucoma medication alone. Survival analysis showed no statistical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>None of the four antiglaucoma medications evaluated statistically delayed medical failure when compared to each other. Although significance was not achieved, our data suggest that adjunctive use of topical anti\u2010inflammatory medications may be beneficial in these cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12069","type":"journal-article","created":{"date-parts":[[2013,7,5]],"date-time":"2013-07-05T09:33:53Z","timestamp":1373016833000},"page":"195-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Efficacy of prophylactic antiglaucoma and anti\u2010inflammatory medications in canine primary angle\u2010closure glaucoma: a multicenter retrospective study (2004\u20132012)"],"prefix":"10.1111","volume":"17","author":[{"given":"D. Dustin","family":"Dees","sequence":"first","affiliation":[{"name":"Eye Care for Animals 1021 E. 3300 S. Salt Lake City UT 84106 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Fritz","sequence":"additional","affiliation":[{"name":"Eye Care for Animals 3025 Edinger Avenue Tustin CA 92780 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole E.","family":"MacLaren","sequence":"additional","affiliation":[{"name":"Eye Care for Animals 1021 E. 3300 S. Salt Lake City UT 84106 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas W.","family":"Esson","sequence":"additional","affiliation":[{"name":"Eye Care for Animals 3025 Edinger Avenue Tustin CA 92780 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annora M.","family":"Sheehan Gaerig","sequence":"additional","affiliation":[{"name":"Eye Care for Animals 3123\u00a0N. 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