{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T09:09:00Z","timestamp":1764493740822},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T00:00:00Z","timestamp":1372291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 22\u2010year\u2010old Australian stockhorse gelding was presented with anterior uveitis in the right eye which was nonresponsive to anti\u2010inflammatory therapy. Clinical examination revealed corneal edema and vascularization, marked hypopyon, and thickening of the dorsal iris, which was confirmed by ultrasonography. Hematologic and biochemical analyses, abdominal and thoracic ultrasonography, and abdominocentesis with cytologic and biochemical analysis revealed no significant abnormalities. Cytological examination of an aqueous humor sample revealed a population of predominantly large lymphoblasts with high nuclear\u2010to\u2010cytoplasmic ratio, round or irregular nuclei, clumped nuclear chromatin, multiple large prominent nucleoli, and a small volume of basophilic cytoplasm. The cytologic diagnosis was intraocular lymphoma. Biopsy of the right submandibular lymph node revealed no evidence of neoplastic invasion. Euthanasia and a complete necropsy were performed and revealed no evidence of neoplasia in any tissue other than the right eye, which had an extensive, well\u2010defined infiltrate of neoplastic lymphocytes expanding the ciliary body and iris, infiltrating the ciliary epithelium, and extending into the pars plana and peripheral choroid. Immunohistochemistry confirmed that neoplastic cells expressed the T\u2010cell marker<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3. To the authors' knowledge, this is the first description of primary, solitary uveal T\u2010cell lymphoma in a horse. Although apparently rare, lymphoma should be considered in horses with uveitis, even when inflammation is unilateral and in the absence of extraocular signs of neoplasia. Aqueocentesis and cytological examination provided an antemortem diagnosis in this case and should be considered as a diagnostic tool for investigation of uveal thickening and hypopyon.<\/jats:p>","DOI":"10.1111\/vop.12078","type":"journal-article","created":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T07:48:55Z","timestamp":1372319335000},"page":"139-145","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Solitary (primary) uveal<scp>T<\/scp>\u2010cell lymphoma in a horse"],"prefix":"10.1111","volume":"17","author":[{"given":"Gareth D.","family":"Trope","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Science University of Melbourne 250 Princes Highway Werribee Melbourne Vic. 3030 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina I.","family":"McCowan","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science University of Melbourne 250 Princes Highway Werribee Melbourne Vic. 3030 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayle","family":"Tyrrell","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science University of Melbourne 250 Princes Highway Werribee Melbourne Vic. 3030 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Lording","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science University of Melbourne 250 Princes Highway Werribee Melbourne Vic. 3030 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Maggs","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine University of California Davis Davis CA 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7216-9540-2.50117-1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2746\/095777308X336327"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3292.2010.00200.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.43-6-914"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0739(17)30187-6"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.115.6.130"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.119.8.178"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2008.00638.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.2460\/javma.1992.201.12.1913","article-title":"Epididymal swelling attributable to generalized lymphosarcoma in a stallion","volume":"201","author":"Held JP","year":"1992","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.42-1-52"},{"key":"e_1_2_5_12_1","first-page":"807","article-title":"Lymphosarcoma with leukemia in a horse","volume":"43","author":"Madewell BR","year":"1982","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2008.07.008"},{"key":"e_1_2_5_14_1","first-page":"939","article-title":"Bilateral eyelid swelling attributable to lymphosarcoma in a horse","volume":"194","author":"Murphy CJ","year":"1989","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1988.tb01480.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2005.00349.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.2012.01015.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2012.01016.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985812451603"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589803500402"},{"key":"e_1_2_5_21_1","doi-asserted-by":"crossref","first-page":"852","DOI":"10.2460\/javma.1998.212.06.852","article-title":"Ocular lesions in horses with lymphosarcoma: 21 cases (1977\u20101997)","volume":"212","author":"Rebhun WC","year":"1998","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)78239-X"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1986.tb00616.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2000.3230153.x"},{"key":"e_1_2_5_25_1","first-page":"492","article-title":"Ocular changes in malignant lymphoma of dogs","volume":"52","author":"Cello RM","year":"1962","journal-title":"The Cornell Veterinarian"},{"key":"e_1_2_5_26_1","first-page":"127","article-title":"Prevalence of ocular involvement in dogs with multicentric lymphoma: prospective evaluation of 94 cases","volume":"4","author":"Krohne SG","year":"1994","journal-title":"Veterinary and Comparative Ophthalmology"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2002.00217.x"},{"key":"e_1_2_5_28_1","first-page":"35","article-title":"Histopathologic features of feline ocular lymphosarcoma: 49 cases (1978\u20101992)","volume":"5","author":"Corcoran KA","year":"1995","journal-title":"Veterinary and Comparative Ophthalmology"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2012.01025.x"},{"key":"e_1_2_5_30_1","first-page":"837","article-title":"Lymphocytic lymphosarcoma of the canine eye","volume":"147","author":"Whitford EL","year":"1965","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-012-0150-7"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-011-0618-1"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820530500350498"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2005.05.011"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1993.tb02947.x"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.2746\/095777308X332231"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273940903108544"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01531.x"},{"key":"e_1_2_5_39_1","first-page":"699","volume-title":"Small Animal Clinical Oncology","author":"Vail D","year":"2002"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.229.10.1617"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.230.10.1506"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3292.2004.tb00318.x"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvop.12078","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.12078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:47:28Z","timestamp":1715568448000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.12078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,27]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/vop.12078"],"URL":"https:\/\/doi.org\/10.1111\/vop.12078","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,27]]},"assertion":[{"value":"2013-06-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}