{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:41:17Z","timestamp":1788824477411,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To characterize and describe the histopathologic findings in equine globes enucleated due to glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records at The Ohio State University from 1999 to 2012 were reviewed retrospectively. Signalment, history, and treatment data were collected, and histologic slides of enucleated globes were examined and lesions recorded. Twenty\u2010three eyes from 23 horses were eligible for inclusion in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The majority of affected horses were &gt; 15\u00a0years of age (65%). The ages ranged from 5 to 35\u00a0years (mean\u00a0=\u00a017.4\u00a0years). The left eye was affected in 10 cases (43%) and the right eye in 13 cases (57%). There were 13 mares (56%) and 10 geldings (44%). Quarter Horses (30%), Appaloosas (26%), and Thoroughbreds (22%) were the most common breeds in the study population. The most common histopathologic changes included hypercellularity of the optic nerve (93%), retinal atrophy (89%), corneal vascularization (83%), descemetization of pectinate ligaments (83%), hypercellularity of the anterior corneal stroma (75%), posterior bowing of the iris base (74%), ciliary body atrophy (74%), corneal striae (70%), pars plana elongation (60%), cataract (53%), and collapsed ciliary cleft\/trabecular meshwork (52%). Evidence of uveitis (cataract, lymphoplasmacytic infiltration of the uvea, and\/or anterior or posterior synechiae) was present in 20\/23 eyes (87%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Equine glaucoma most commonly occurs secondary to uveitis with Appaloosas and older horses predisposed. Histologic changes are comparable to prior reports of chronic glaucoma; notable findings not previously described in the horse were posterior bowing of the iris base and relative sparing of the superior retina from atrophy associated with elevated<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12080","type":"journal-article","created":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T03:17:21Z","timestamp":1374031041000},"page":"334-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Equine glaucoma: a histopathologic retrospective study (1999\u20132012)"],"prefix":"10.1111","volume":"17","author":[{"given":"Elizabeth M.","family":"Curto","sequence":"first","affiliation":[{"name":"College of Optometry The Ohio State University Columbus OH 43210 USA"},{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine The Ohio State University Columbus OH 43210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne J.","family":"Gemensky\u2010Metzler","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine The Ohio State University Columbus OH 43210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather L.","family":"Chandler","sequence":"additional","affiliation":[{"name":"College of Optometry The Ohio State University Columbus OH 43210 USA"},{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine The Ohio State University Columbus OH 43210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Wilkie","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine The Ohio State University Columbus OH 43210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589102800110"},{"key":"e_1_2_7_3_1","first-page":"105","article-title":"Congenital equine glaucoma: clinical and light microscopic findings in two cases","volume":"7","author":"Halenda RM","year":"1997","journal-title":"Veterinary & Comparative Ophthalmology"},{"key":"e_1_2_7_4_1","first-page":"470","article-title":"Equine glaucoma: a retrospective study of 13 cases presented at the Western College of Veterinary Medicine from 1992 to 1999","volume":"41","author":"Cullen CL","year":"2000","journal-title":"The Canadian Veterinary Journal. La Revue V\u00e9t\u00e9rinaire Canadienne"},{"key":"e_1_2_7_5_1","first-page":"756","article-title":"Equine glaucoma: a retrospective study of 11 cases from 1988 to 1993","volume":"88","author":"Pickett JP","year":"1993","journal-title":"Veterinary Medicine"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2004.04.002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2010.00779.x"},{"key":"e_1_2_7_8_1","first-page":"261","article-title":"Glaucoma and lens luxation in a foal","volume":"68","author":"Gelatt KN","year":"1973","journal-title":"Veterinary Medicine, Small Animal Clinician"},{"key":"e_1_2_7_9_1","first-page":"294","article-title":"Equine glaucoma and diode laser transscleral cyclophotocoagulation: 27 cases","volume":"4","author":"Wilkie DA","year":"2001","journal-title":"Veterinary Ophthalmology"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2746\/095777309X409947"},{"key":"e_1_2_7_11_1","first-page":"170","article-title":"Equine glaucoma: clinical findings and response to treatment in 14 horses","volume":"5","author":"Miller TR","year":"1995","journal-title":"Veterinary & Comparative Ophthalmology"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.2460\/javma.1995.207.10.1327","article-title":"Association of leptospiral seroreactivity and breed with uveitis and blindness in horses: 372 cases (1986\u20131993)","volume":"207","author":"Dwyer AE","year":"1995","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2010.tb05637.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-0846-2.00009-4"},{"key":"e_1_2_7_15_1","first-page":"1233","volume-title":"Veterinary Ophthalmology","author":"Brooks DE","year":"2007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1999.00083.x"},{"key":"e_1_2_7_17_1","first-page":"E1","article-title":"Effect of semiconductor diode transscleral cyclophotocoagulation (TSCP) in buphthalmic equine globes. ACVO","volume":"16","author":"Gemensky\u2010Metzler AJ","year":"2012","journal-title":"Veterinary Ophthalmology"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5216.2001.00147.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589002700106"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2011.00949.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2009.00739.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2003.00297.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-2797-0.00013-8"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.37.11.670"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00210.2003"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20105224.2012.01019.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2005.00399.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1998.00018.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2000.00151.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2009.00732.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(93)90008-U"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1529-1839(04)70023-8"},{"key":"e_1_2_7_33_1","first-page":"2445","article-title":"Unconventional aqueous humor outflow of microspheres perfused into the equine eye","volume":"47","author":"Smith PJ","year":"1986","journal-title":"American journal of veterinary research"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2011.00914.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00436-X"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvop.12080","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.12080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T21:07:59Z","timestamp":1715720879000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.12080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,16]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/vop.12080"],"URL":"https:\/\/doi.org\/10.1111\/vop.12080","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,16]]},"assertion":[{"value":"2013-07-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}