{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T21:07:22Z","timestamp":1775509642993,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterize the histopathological causes for failure of intrascleral prosthesis placement in dogs and cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>The Comparative Ocular Pathology Laboratory of Wisconsin database was searched to find canine and feline evisceration samples that were diagnosed with neoplasia. A second population included canine and feline scleral shells that were removed after an evisceration surgery had been performed. The causes for removal were divided into: neoplasia, corneal abnormalities, and other causes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In dogs, 163 of 1985 evisceration samples (8.21%) contained a neoplasm, whereas 17 of 88 (19.31%) evisceration samples in cats contained a neoplasm. In dogs, severe corneal disease was diagnosed in 38 of 80 scleral shells (46.25%) and neoplasia was diagnosed in 31 of 80 scleral shells (38.75%). Malignant melanoma was the most frequently diagnosed tumor, in 14 of 31 scleral shells. In cats, eight of 12 scleral shells contained a tumor (66.7%), with feline diffuse iris melanoma being diagnosed most commonly (six of eight shells). Two of 12 feline scleral shells had severe corneal disease (16.7%). Epithelial downgrowth, lining the inner aspect of the fibrous tunic, was seen in 14 of 38 canine scleral shells and in two of two feline scleral shells with severe corneal disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Severe corneal disease and neoplasia are the most common causes for intrascleral prosthesis failure in dogs, whereas neoplasia is the single most common cause for intrascleral prosthesis failure in cats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12082","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T08:29:45Z","timestamp":1375345785000},"page":"343-350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Histopathological study of the causes for failure of intrascleral prostheses in dogs and cats"],"prefix":"10.1111","volume":"17","author":[{"given":"Carolina","family":"Naranjo","sequence":"first","affiliation":[{"name":"Departamento de Medicina y Cirug\u00eda Animales Universidad Complutense de Madrid Avda. Puerta de Hierro s\/n 28040 Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard R.","family":"Dubielzig","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences School of Veterinary Medicine University of Wisconsin\u2010Madison 2015 Linden Drive Madison WI 53706 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Small Animal Ophthalmic Surgery: Practical Tecnhiques for the Veterinarian","author":"Gelatt KN","year":"1991"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-072160561-6.50020-4"},{"key":"e_1_2_6_4_1","first-page":"481","article-title":"Intraocular prosthesis in the dog","volume":"13","author":"Brightman AH","year":"1977","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_6_5_1","first-page":"539","volume-title":"Veterinary Ophthalmology","author":"Spiess BM","year":"2007"},{"key":"e_1_2_6_6_1","first-page":"883","article-title":"Intraocular prosthesis in the dog and cat: the failures","volume":"179","author":"Koch SA","year":"1981","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_6_7_1","first-page":"66","article-title":"Intraocular Silicone Prostheses in dogs: a review of the literature and 50 new cases","volume":"30","author":"Hamor RE","year":"1994","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_6_8_1","first-page":"1443","article-title":"Intraocular findings in three dogs and one cat with chronic glaucoma","volume":"191","author":"McLaughlin SA","year":"1987","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.2460\/javma.1995.207.11.1441","article-title":"Intraocular silicone prosthesis implantation in eyes of dogs and a cat with intraocular neoplasia: nine cases (1983\u20131994)","volume":"207","author":"McLaughlin SA","year":"1995","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.69.847"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-1549(01)00013-X"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctsap.2007.12.004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2009.00691.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.2460\/javma.1990.196.04.617","article-title":"Intraocular silicone prostheses in a dog and a horse with corneal lacerations","volume":"196","author":"Riggs C","year":"1990","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2007.00524.x"},{"key":"e_1_2_6_16_1","first-page":"245","article-title":"Absolute corneal sensitivity and corneal trigeminal nerve anatomy in normal dogs","volume":"1","author":"Barrett PM","year":"1991","journal-title":"Progress in Veterinary and Comparative Ophthalmology"},{"key":"e_1_2_6_17_1","volume-title":"Ocular Pathology","author":"Yanoff M","year":"2009"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(63)90184-3"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(65)92259-2"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.9.1268"},{"key":"e_1_2_6_21_1","first-page":"943","article-title":"Intraocular epithelial downgrowth in a dog","volume":"48","author":"Kostuik H","year":"2007","journal-title":"The Canadian Veterinary Journal"},{"key":"e_1_2_6_22_1","first-page":"812","volume-title":"Veterinary Ophthalmology","author":"Hendrix DVH","year":"2007"},{"key":"e_1_2_6_23_1","volume-title":"Veterinary Ocular Pathology. 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