{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:56:53Z","timestamp":1789516613871,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T00:00:00Z","timestamp":1378166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 7\u2010month\u2010old male intact <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>oerboel presented to the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ummings <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>chool of <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>eterinary <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edicine at <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>ufts <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity for the evaluation of ocular discharge. Bilateral multifocal serous retinal detachments were noted on fundus examination as an incidental finding. Genetic testing confirmed the dog to be homozygous for a mutation in the <jats:italic><jats:styled-content style=\"fixed-case\">BEST<\/jats:styled-content>1<\/jats:italic> gene, where a <jats:styled-content style=\"fixed-case\">C<jats:sub>73<\/jats:sub>T\/R<jats:sub>25<\/jats:sub>X<\/jats:styled-content> change results in premature termination codon. Further testing, including electroretinography and optical coherence tomography (<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>), demonstrated that there was no evidence of retinal photoreceptor dysfunction and confirmed that observed lesions were characteristic of canine multifocal retinopathy. No progression of the lesions was noted 3\u00a0months after the initial examination. To the authors\u2019 knowledge, this is the first report of canine multifocal retinopathy in the <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>oerboel breed.<\/jats:p>","DOI":"10.1111\/vop.12095","type":"journal-article","created":{"date-parts":[[2013,9,3]],"date-time":"2013-09-03T12:11:59Z","timestamp":1378210319000},"page":"368-372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Canine multifocal retinopathy caused by a <i><scp>BEST<\/scp>1<\/i> mutation in a <scp>B<\/scp>oerboel"],"prefix":"10.1111","volume":"17","author":[{"given":"Kara R.","family":"Gornik","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Tufts Cummings School of Veterinary Medicine 200 Westboro Road North Grafton MA 01536 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Pirie","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Tufts Cummings School of Veterinary Medicine 200 Westboro Road North Grafton MA 01536 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay S.","family":"Duker","sequence":"additional","affiliation":[{"name":"New England Eye Center Tufts Medical Center 260 Tremont St. Biewend Building 9 Boston MA 02111 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy J.","family":"Boudrieau","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Tufts Cummings School of Veterinary Medicine 200 Westboro Road North Grafton MA 01536 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1998.00041.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-1374"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2012.01005.x"},{"key":"e_1_2_5_5_1","first-page":"2791","article-title":"Assessment of canine BEST1 variations identifies new mutations and establishes an independent bestretinopathy model (cmr3)","volume":"16","author":"Zangerl B","year":"2010","journal-title":"Molecular Vision"},{"key":"e_1_2_5_6_1","first-page":"929","article-title":"Diagnostic ophthalmology","volume":"47","author":"Grahn BH","year":"2006","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2008.00632.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5216.2001.00154.x"},{"key":"e_1_2_5_9_1","first-page":"893","article-title":"Diagnostic ophthalmology","volume":"40","author":"Grahn BH","year":"1999","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_5_10_1","first-page":"491","article-title":"Diagnostic ophthalmology","volume":"47","author":"Grahn BH","year":"2006","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2011.00963.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020524305726"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.09.057"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvop.12095","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.12095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T16:24:33Z","timestamp":1696177473000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.12095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,3]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/vop.12095"],"URL":"https:\/\/doi.org\/10.1111\/vop.12095","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,3]]},"assertion":[{"value":"2013-09-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}