{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:28:33Z","timestamp":1788791313382,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T00:00:00Z","timestamp":1378944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Two of the authors (<jats:styled-content style=\"fixed-case\">DG<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">BS<\/jats:styled-content>) independently observed that a number of Flat\u2010Coated Retrievers (<jats:styled-content style=\"fixed-case\">FCR<\/jats:styled-content>s) previously unaffected by pectinate ligament dysplasia (<jats:styled-content style=\"fixed-case\">PLD<\/jats:styled-content>) appeared to develop the condition later in life. This study was instigated to investigate progression of<jats:styled-content style=\"fixed-case\">PLD<\/jats:styled-content>within individual dogs over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals studied<\/jats:title><jats:p>Flat\u2010Coated Retrievers that had previously undergone gonioscopy under the<jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ECVO<\/jats:styled-content>hereditary eye schemes were included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>A second gonioscopic examination was performed 1.92\u201312.58\u00a0years later (mean 6, median 5.75\u00a0years) and the results compared. 39<jats:styled-content style=\"fixed-case\">FCR<\/jats:styled-content>(17 males, 22 females) in the<jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>and 57<jats:styled-content style=\"fixed-case\">FCR<\/jats:styled-content>(27 males, 30 females) in Switzerland were included. Slit\u2010lamp biomicroscopy, indirect ophthalmoscopy, and gonioscopy were performed in all dogs. Gonioscopy allowed classification as either unaffected or affected; percentage of the iridocorneal drainage angle (<jats:styled-content style=\"fixed-case\">ICA<\/jats:styled-content>) affected by<jats:styled-content style=\"fixed-case\">PLD<\/jats:styled-content>was determined, before calculating progression observed as mild, moderate, or severe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>39 of 96 (40.6%) dogs demonstrated progression of<jats:styled-content style=\"fixed-case\">PLD<\/jats:styled-content>(<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Of these, 13 of 96 (13.5%) were classified as mild progression (from either unaffected to 10\u201320% or 10\u201320% to 20\u201390%<jats:styled-content style=\"fixed-case\">ICA<\/jats:styled-content>affected). Progression was more extensive in 26 of 96 (27.1%) dogs (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), of which 12 of 96 (12.5%) went from unaffected to severe<jats:styled-content style=\"fixed-case\">PLD<\/jats:styled-content>of &gt;90%<jats:styled-content style=\"fixed-case\">ICA<\/jats:styled-content>affected, consistent with a high risk of glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To the authors' knowledge, this is the first report describing progression of<jats:styled-content style=\"fixed-case\">PLD<\/jats:styled-content>in individual dogs over time, in a breed affected by primary, angle closure glaucoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12098","type":"journal-article","created":{"date-parts":[[2013,9,12]],"date-time":"2013-09-12T11:39:30Z","timestamp":1378985970000},"page":"6-12","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Progression of pectinate ligament dysplasia over time in two populations of Flat\u2010Coated Retrievers"],"prefix":"10.1111","volume":"18","author":[{"given":"Rose","family":"Pearl","sequence":"first","affiliation":[{"name":"Davies Veterinary Specialists Manor Farm Business Park Higham Gobion Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gould","sequence":"additional","affiliation":[{"name":"Davies Veterinary Specialists Manor Farm Business Park Higham Gobion Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Spiess","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty Equine Department University of Zurich Winterthurerstrasse 260 8057 Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,12]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"753","volume-title":"Veterinary Ophthalmology","author":"Gelatt KN","year":"2007"},{"key":"e_1_2_6_3_1","first-page":"149","volume-title":"Veterinary Ophthalmology","author":"Gum GG","year":"2007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1998.00019.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1998.00020.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1969.tb04035.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1975.tb05739.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1977.tb05831.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1977.tb05830.x"},{"key":"e_1_2_6_10_1","first-page":"180","article-title":"The normal canine iridocorneal angle as viewed with the scanning electron microscope","volume":"11","author":"Martin CL","year":"1975","journal-title":"Journal of American Animal Hospital Association"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713688409000790"},{"key":"e_1_2_6_12_1","unstructured":"British Veterinary Association\/Kennel Club\/International Sheep Dog Society Eye Scheme.Information for panellists. 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