{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:57:00Z","timestamp":1770746220627,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T00:00:00Z","timestamp":1381968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect on globe position and respiration of three dosages of intravenous rocuronium in isoflurane\u2010anesthetized dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal studied<\/jats:title><jats:p>Thirty\u2010two dogs anesthetized for ophthalmic procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>The dogs were divided into four groups, each of eight animals (G1\u2010G4). G1, G2, G3 received 0.075, 0.05, 0.03\u00a0mg\/kg of IV rocuronium, respectively; G4 received 0.9% NaCl IV; all the treatments were administered when an end\u2010tidal isoflurane of 1.1\u20131.2% was reached. Anesthesia was obtained with dexmedetomidine (2.5\u00a0mcg\/kg IV), methadone (0.1\u00a0mg\/kg IV), propofol (2\u00a0mg\/kg IV), and isoflurane in oxygen. Neuromuscular function was assessed with acceleromyography by stimulation of the peroneal nerve using the train\u2010of\u2010four (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>oF) and the ToF ratio (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>oFR). Monitoring of cardiovascular and respiratory functions was performed. Changes in globe position were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All three dosages of rocuronium produced centralization of the globe. Duration was 24.3\u00a0\u00b1\u00a04.2, 23.4\u00a0\u00b1\u00a03.6, and 8.7\u00a0\u00b1\u00a02.8\u00a0min, for G1, G2, and G3, respectively. The control group did not show globe centralization. No significant differences were found among the four groups in cardiovascular and respiratory parameters. Minute volume and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>oFR were significantly lower in G1 compared with baseline values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>All doses of rocuronium resulted in globe centralization. The higher dose provoked a transient respiratory depression and some degree of skeletal muscular blockade detectable with <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>oFR. No alterations in respiratory activity were present when 0.05\u00a0mg\/kg was used. The 0.03\u00a0mg\/kg dosage could be useful for very short ophthalmic procedures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12108","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T07:33:03Z","timestamp":1381995183000},"page":"89-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effects of rocuronium bromide on globe position and respiratory function in isoflurane\u2010anesthetized dogs: a comparison between three different dosages"],"prefix":"10.1111","volume":"18","author":[{"given":"Angela","family":"Briganti","sequence":"first","affiliation":[{"name":"Department of Veterinary Science University of Pisa Via Livornese, lato monte 56122 San Piero a Grado Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Barsotti","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science University of Pisa Via Livornese, lato monte 56122 San Piero a Grado Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego A.","family":"Portela","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science University of Pisa Via Livornese, lato monte 56122 San Piero a Grado Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Di Nieri","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science University of Pisa Via Livornese, lato monte 56122 San Piero a Grado Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Breghi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science University of Pisa Via Livornese, lato monte 56122 San Piero a Grado Pisa 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