{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T14:34:51Z","timestamp":1769092491354,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T00:00:00Z","timestamp":1388361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Corneal collagen cross\u2010linking with riboflavin and <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\u2010A (<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>) decreases corneal oedema and increases visual acuity in human patients with bullous keratopathy. Presumed mechanisms are an increase in collagen packing density and a reduction in stromal swelling pressure. We present two cases in which <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> was used to treat bullous keratopathy in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>Four eyes of two dogs with painful bullous keratopathy\u2010induced corneal erosions that were resistant to prior therapy were treated with <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>. Both corneas of the second patient were dehydrated to\u00a0\u00b1\u00a0400\u00a0\u03bcm corneal thickness using topical 70% glycerol solution immediately prior to <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>. Follow\u2010up included slit\u2010lamp examination, fluorescein staining and photographic documentation in both cases and high\u2010resolution ultrasound examination in the second patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All four eyes were comfortable and fluorescein negative at 1\u2010week post\u2010<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> and remained so for the rest of the follow\u2010up period (17.5\u00a0months for case 1 and 6\u00a0months for case 2). The owner of the first patient reported a less oedematous cornea and improvement in vision that lasted for 6\u00a0months. Despite a reported lack of improvement in vision in the second patient, corneal thickness initially decreased, but was back at baseline thickness at the 4\u2010month recheck.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Similar to humans, <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> might become a useful treatment option for bullous keratopathy\u2010induced therapy\u2010resistant corneal erosions in dogs. Patient comfort was greatly improved, but corneal thickness decrease was not as long\u2010lasting as reported for humans. The presently used protocols might need modification to fit the dog cornea.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12137","type":"journal-article","created":{"date-parts":[[2013,12,30]],"date-time":"2013-12-30T06:54:42Z","timestamp":1388386482000},"page":"168-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Treatment of bullous keratopathy with corneal collagen cross\u2010linking in two dogs"],"prefix":"10.1111","volume":"18","author":[{"given":"Simon A.","family":"Pot","sequence":"first","affiliation":[{"name":"Equine Department Vetsuisse Faculty University of Zurich Winterthurerstrasse 260 CH\u20108057 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolin S.","family":"Gallh\u00f6fer","sequence":"additional","affiliation":[{"name":"Equine Department Vetsuisse Faculty University of Zurich Winterthurerstrasse 260 CH\u20108057 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ladina","family":"Walser\u2010Reinhardt","sequence":"additional","affiliation":[{"name":"Vetaugenblick, Tierklinik Masans Masanserstrasse 143 CH\u20107000 Chur Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhad","family":"Hafezi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Geneva University Hospitals Rue Alcide\u2010Jentzer 22 CH\u20101211 Geneva 14 Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard M.","family":"Spiess","sequence":"additional","affiliation":[{"name":"Equine Department Vetsuisse Faculty University of Zurich Winterthurerstrasse 260 CH\u20108057 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3180334f78"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052860"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10346"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713680490513182"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(03)00407-3"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200401000-00008"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318030df5a"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31818225c3"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)02220-1"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318169d698"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2007.01085.x"},{"key":"e_1_2_5_13_1","first-page":"690","article-title":"Diseases and surgery of the canine cornea and sclera","author":"Gilger BC","year":"2007","journal-title":"Veterinary Ophthalmology"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12027"},{"key":"e_1_2_5_15_1","unstructured":"FamoseF.Evaluation of accelerated collagen cross\u2010linking for the treatment of refractory deep keratitis in 8 dogs and 10 cats.Annual Meeting of the European College of Veterinary Ophthalmologists Barcelona 2013."},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-9-128"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12090"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.222.607"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.162479"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000187630"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20090813-08"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181c296c2"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2009.07.041"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.10.052"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2006.11.015"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13\u201011807"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/jtbi.1993.1115"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2005.12.092"},{"key":"e_1_2_5_29_1","first-page":"795","volume-title":"Adler's Physiology of the Eye","author":"Dawson DG","year":"2011"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700574"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvop.12137","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.12137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T14:19:09Z","timestamp":1696169949000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.12137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,30]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/vop.12137"],"URL":"https:\/\/doi.org\/10.1111\/vop.12137","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,30]]},"assertion":[{"value":"2013-12-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}