{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:48:47Z","timestamp":1793393327966,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T00:00:00Z","timestamp":1391990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To review the signalment, clinical characteristics, and outcome of horses with nonhealing corneal ulcers treated with diamond burr debridement (<jats:styled-content style=\"fixed-case\">DBD<\/jats:styled-content>); and to evaluate the role of ulcer duration, size and location, and bandage contact lens (<jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>) placement on healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>From January 2012\u2013April 2013, 60 horses were diagnosed with ulcers classified as nonhealing based on the presence of raised epithelial margins and duration of at least 7\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Retrospective record review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Average age of included horses was 14.68\u00a0years, <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 8.17\u00a0years. There were three times as many males (45) as females (15), (<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/vop12148-math-0001.gif\" xlink:title=\"urn:x-wiley:14635216:media:vop12148:vop12148-math-0001\"\/> = 15, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Forty\u2010eight horses (80%) had nonhealing ulcers uncomplicated by associated corneal disease. In the remaining horses, associated corneal disease included esinophilic keratitis (10%), calcific band keratopathy (5%), endothelial decompensation (1.67%), habronemiasis(1.67%), and lid suture abrasion (1.67%). Average corneal ulcer duration prior to diamond burr debridement (<jats:styled-content style=\"fixed-case\">DBD<\/jats:styled-content>) was 29.0\u00a0days (<jats:italic>n<\/jats:italic>\u00a0=\u00a056). Ulcers occurred most commonly in the axial cornea (41%). Fifty\u2010five of 60 horses (92%) healed with <jats:styled-content style=\"fixed-case\">DBD<\/jats:styled-content>. Healing time, defined as time to epithelialization following <jats:styled-content style=\"fixed-case\">DBD<\/jats:styled-content>, averaged 15.5\u00a0days, <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> 9.32\u00a0days, and was not correlated with patient age or ulcer duration, location, or size prior to or following <jats:styled-content style=\"fixed-case\">DBD<\/jats:styled-content>. Healing time was significantly longer for eyes in which a <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content> had been placed (<jats:italic>n<\/jats:italic>\u00a0=\u00a028, 19.0\u00a0days) than for eyes without a <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a032, 12.9\u00a0days), <jats:italic>F<\/jats:italic>(1,58) = 5.543, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02. <jats:styled-content style=\"fixed-case\">DBD<\/jats:styled-content> was considered a failure for five horses (8%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DBD<\/jats:styled-content> may be an effective treatment for nonhealing corneal ulcers in horses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12148","type":"journal-article","created":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T09:18:38Z","timestamp":1392023918000},"page":"76-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Treatment of nonhealing corneal ulcers in 60 horses with diamond burr debridement (2010\u20132013)"],"prefix":"10.1111","volume":"17","author":[{"given":"Mary","family":"Lassaline\u2010Utter","sequence":"first","affiliation":[{"name":"New Bolton Center University of Pennsylvania School of Veterinary Medicine Kennett Square PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim J.","family":"Cutler","sequence":"additional","affiliation":[{"name":"Equine Eye Care Wellington FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy M.","family":"Michau","sequence":"additional","affiliation":[{"name":"Surgi\u2010Care Center for Horses Brandon FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Nunnery","sequence":"additional","affiliation":[{"name":"Equine Veterinary Vision Alexandria VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,10]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"2262","article-title":"Morphology and immunohistochemistry of spontaneous chronic corneal epithelial defects (SCCED) in dogs","volume":"42","author":"Bentley E","year":"2001","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_6_3_1","first-page":"2136","article-title":"The effect of chronic corneal epithelial debridement on epithelial and stromal morphology in dogs","volume":"43","author":"Bentley E","year":"2002","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_6_4_1","first-page":"2252","article-title":"Spontaneous chronic corneal epithelial defects (SCCED) in dogs: clinical features, innervation, and effect of topical SP, with or without IGF\u20101","volume":"42","author":"Murphy CJ","year":"2001","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.82.1.26"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.5326\/0410158"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e32832c9716"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.3.296"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31818526ec"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2012.01026.x"},{"key":"e_1_2_6_11_1","first-page":"390","article-title":"A retrospective evaluation of the diamond burr superficial keratectomy in the treatment of spontaneous chronic corneal epithelial defects in dogs from 2006 to 2008.\u00a0<br\/>Abstracts: 40th Annual Meeting of the American College of Veterinary Ophthalmologists, Chicago, IL, USA November 4\u20137, 2009","volume":"12","author":"Sila GH","year":"2009","journal-title":"Veterinary Ophthalmology"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2010.00869.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2003.00309.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2007.00526.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.74.7.1030"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2000.3230133.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2003.00283.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12076"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvop.12148","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.12148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T02:14:43Z","timestamp":1694484883000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.12148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,10]]},"references-count":17,"journal-issue":{"issue":"s1","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/vop.12148"],"URL":"https:\/\/doi.org\/10.1111\/vop.12148","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,10]]},"assertion":[{"value":"2014-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}