{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T01:12:14Z","timestamp":1792977134404,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T00:00:00Z","timestamp":1399248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To describe the use, tolerability, and efficacy of episcleral silicone matrix cyclosporine (<jats:styled-content style=\"fixed-case\">ESMC<\/jats:styled-content>) implants in dogs with keratoconjunctivitis sicca (<jats:styled-content style=\"fixed-case\">KCS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study.<jats:styled-content style=\"fixed-case\">ESMC<\/jats:styled-content>implants (1.9\u00a0cm length, 30% wt\/wt<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>s<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>in silicone; with approximately 12\u00a0mg of<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>s<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>loaded into them) were used in dogs with<jats:styled-content style=\"fixed-case\">KCS<\/jats:styled-content>responsive to topical<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>s<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>(good candidate,<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>) or not responsive (poor candidate,<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>). Ocular surface inflammation scores, Schirmer tear test (<jats:styled-content style=\"fixed-case\">STT<\/jats:styled-content>) values, and ocular discharge quantity were evaluated and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven eyes (15 dogs) received an<jats:styled-content style=\"fixed-case\">ESMC<\/jats:styled-content>implant for<jats:styled-content style=\"fixed-case\">KCS<\/jats:styled-content>; 15 eyes were considered<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>, and 12 were considered<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>. Both<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>eyes and<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>eyes showed a significant increase in<jats:styled-content style=\"fixed-case\">STT<\/jats:styled-content>values (increase of 7.7 and 8.5\u00a0mm\/min;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.023 and<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003, respectively) after placement of<jats:styled-content style=\"fixed-case\">ESMC<\/jats:styled-content>implants (mean follow\u2010up 18\u00a0\u00b1\u00a02 and 10.4\u00a0\u00b1\u00a015\u00a0months, respectively). Clinical signs improved significantly in both groups during the same follow\u2010up, with reduction in conjunctival hyperemia (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), corneal neovascularization (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004), corneal opacity (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003), and ocular discharge (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002).<jats:styled-content style=\"fixed-case\">ESMC<\/jats:styled-content>implants were well tolerated by all dogs, but two eyes lost the device at 12\u2010months and 1\u2010week follow\u2010up, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results from this study suggest that the<jats:styled-content style=\"fixed-case\">EMSC<\/jats:styled-content>implants were well tolerated and efficacious in dogs with<jats:styled-content style=\"fixed-case\">KCS<\/jats:styled-content>responsive to topical<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>s<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>as well as dogs with poor response to topical therapy. Further study is needed to determine the duration of efficacy and optimal dose of<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>s<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12173","type":"journal-article","created":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T21:55:28Z","timestamp":1399326928000},"page":"234-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Use of episcleral cyclosporine implants in dogs with keratoconjunctivitis sicca: pilot study"],"prefix":"10.1111","volume":"18","author":[{"given":"Laura","family":"Barachetti","sequence":"first","affiliation":[{"name":"Department of Veterinary Science and Public Health Faculty of Veterinary Medicine University of Milan Milan 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