{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:40:31Z","timestamp":1762101631560,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T00:00:00Z","timestamp":1417046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the clinical course, outcomes, and complications associated with use of commercially available porcine urinary bladder extracellular matrix (<jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>) grafts (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>ell<jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>et<jats:sup>\u00ae<\/jats:sup><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>orneal<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>iscs) in equid patients with keratomalacia, and to evaluate the efficacy of<jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>grafts as a viable alternative to other biomaterials for corneal grafting in equid patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Sixteen horses and one donkey (17 eyes) with unilateral keratomalacia severe enough to warrant surgical repair between<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ugust 2012 and<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>eptember 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Retrospective medical record review to identify equid patients meeting inclusion criteria of (i) diagnosis with keratomalacia severe enough to warrant surgical repair and (ii) surgical repair with an extracellular matrix graft.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven geldings, four mares, and two colts met inclusion criteria. Patients averaged 9\u00a0years of age. Twelve of 17 eyes (71%) were considered infected based on either corneal cytology (10\/17, or 59%) or corneal culture (12\/17, or 71%) positive for bacteria (8\/17, or 47%) or fungi (9\/17, or 53%). At the time topical medications were discontinued, 16 eyes (94%) were visual. One operated eye ruptured 5\u00a0days postoperatively and was enucleated. Keratouveitis developed in 14\/14 eyes that underwent regular examinations approximately 2\u00a0weeks postoperatively which responded to systemic nonsteroidal anti\u2010inflammatory drug therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Extracellular matrix grafts may be a viable alternative to other biomaterials for corneal grafting in equids. Advantages include commercial availability and shelf storage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12240","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T15:57:44Z","timestamp":1417190264000},"page":"3-10","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Porcine urinary bladder extracellular matrix grafts (<scp>AC<\/scp>ell<scp>V<\/scp>et<sup>\u00ae<\/sup><scp>C<\/scp>orneal<scp>D<\/scp>iscs) for keratomalacia in 17 equids (2012\u20132013)"],"prefix":"10.1111","volume":"19","author":[{"given":"Laura A.","family":"Mancuso","sequence":"first","affiliation":[{"name":"New Bolton Center School of Veterinary Medicine University of Pennsylvania 382 W. Street Road Kennett Square PA 19348 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Lassaline","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine University of California\u2010Davis One Shields Avenue Davis CA 95616 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole M.","family":"Scherrer","sequence":"additional","affiliation":[{"name":"New Bolton Center School of Veterinary Medicine University of Pennsylvania 382 W. 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