{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T16:43:23Z","timestamp":1775321003632,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T00:00:00Z","timestamp":1418947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of this study was to investigate the inheritance and phenotype of retinal dysplasia (<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>) in the American pit bull terrier.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals Studied<\/jats:title><jats:p>A breeding colony established from a single female pure\u2010bred American pit bull terrier dog with<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>A female pure\u2010bred American pit bull terrier with<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>was donated to the Veterinary Hospital of Federal University of Paran\u00e1, Curitiba, Brazil. A breeding colony was established and the phenotype and inheritance of the condition investigated. Regular ophthalmic examinations and fundus photography were performed on three generations of offspring from the founder animal. Some animals were additionally studied by optical coherence tomography. Ocular histopathology was performed on some animals from the colony.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010seven offspring were produced in two generations from the affected founder female. Thirty\u2010two were diagnosed with<jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content>and showed a spectrum of severity of lesions including multifocal, and or geographic lesions and some developed retinal detachment. Histologic examination demonstrated retinal folds, rosettes, and areas of retinal detachment. The affected dogs were shorter in stature than the unaffected littermates. Breeding studies suggested the trait has an autosomal dominant mode of inheritance.<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>testing showed that the affected dogs were negative for the known gene mutations for canine dwarfism with RD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is a report of a novel inherited form of RD that affects American pit bull terriers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12243","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T11:02:11Z","timestamp":1418986931000},"page":"11-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Retinal dysplasia in<scp>A<\/scp>merican pit bull terriers \u2013 phenotypic characterization and breeding study"],"prefix":"10.1111","volume":"19","author":[{"given":"Ana Carolina Veiga","family":"Rodarte\u2010Almeida","sequence":"first","affiliation":[{"name":"Veterinary Medicine Department Federal University of Paran\u00e1 Rua dos Funcion\u00e1rios, 1540 Juvev\u00ea Curitiba PR 80035\u2010050 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Petersen\u2010Jones","sequence":"additional","affiliation":[{"name":"Small Animal Clinical Sciences Veterinary Medical Center Michigan State University 736 Wilson Road D\u2010208 East Lansing MI 48824 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingeborg M.","family":"Langohr","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences School of Veterinary Medicine 1909 Skip Bertman Drive Baton Rouge LA 70803 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Occelli","sequence":"additional","affiliation":[{"name":"Small Animal Clinical Sciences Veterinary Medical Center Michigan State University 736 Wilson Road D\u2010208 East Lansing MI 48824 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peterson T.","family":"Dornbusch","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Department Federal University of Paran\u00e1 Rua dos Funcion\u00e1rios, 1540 Juvev\u00ea Curitiba PR 80035\u2010050 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoye","family":"Shiokawa","sequence":"additional","affiliation":[{"name":"Retina e V\u00edtreo Consultoria Rua Mateus Leme 2285 Curitiba PR 80530-010 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiano","family":"Montiani\u2010Ferreira","sequence":"additional","affiliation":[{"name":"Veterinary Medicine Department Federal University of Paran\u00e1 Rua dos Funcion\u00e1rios, 1540 Juvev\u00ea Curitiba PR 80035\u2010050 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.2460\/ajvr.1972.33.12.2399","article-title":"Development of the canine eye","volume":"33","author":"Aguirre GD","year":"1972","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_6_3_1","first-page":"1492","article-title":"Dysplastic canine retinal morphogenesis","volume":"32","author":"Whiteley HE","year":"1991","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00143890"},{"key":"e_1_2_6_5_1","first-page":"10","article-title":"Retinal dysplasia in the dog","volume":"39","author":"Millichamp NJ","year":"1985","journal-title":"California Veterinary"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(80)50037-9"},{"key":"e_1_2_6_7_1","first-page":"869","volume-title":"Veterinary Ophthalmology","author":"Narfstr\u00f6m K","year":"1999"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1999.00051.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2004.04013.x"},{"key":"e_1_2_6_10_1","first-page":"134","article-title":"Mitochondrial transcription factor A (Tfam) gene sequencing and mitochondrial evaluation in inherited retinal dysplasia in miniature schnauzer dogs","volume":"75","author":"Bauer BS","year":"2011","journal-title":"Canadian Journal of Veterinary Research"},{"key":"e_1_2_6_11_1","first-page":"267","article-title":"Canine herpes\u2010induced retinal dysplasia and associated ocular anomalies","volume":"15","author":"Albert DM","year":"1976","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_6_12_1","first-page":"325","article-title":"Retinal neoplasia and dysplasia. 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