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The incisional biopsy diagnosis was a presumptive corneal hemangiosarcoma. Transpalpebral enucleation was performed, and histopathologic evaluation confirmed angiosarcoma of the conjunctiva, cornea, and extraocular muscles. The horse developed progressive epistaxis and orbital swelling following surgery. A systemic workup was performed 3\u00a0months after enucleation, revealing regrowth within the orbit and marked cranial cervical lymphomegaly, suggestive of metastasis. Humane euthanasia was performed, and necropsy confirmed a locally invasive periorbital tumor with metastasis to the submandibular tissue, submandibular lymph node, and thoracic inlet. Histopathologic evaluation of necropsy specimens revealed polygonal to spindle neoplastic cells lining neoplastic vascular channels lacking erythrocytes. Immunohistochemically, the neoplastic cells labeled strongly positive for<jats:styled-content style=\"fixed-case\">PROX<\/jats:styled-content>\u20101, vimentin,<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\u201031,<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>, weakly positive for factor<jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content>\u2010related antigen, and negative for collagen<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>. Based on the clinical, histological, and immunohistochemical features of this tumor, a primary ocular lymphangiosarcoma with metastasis was diagnosed.<\/jats:p>","DOI":"10.1111\/vop.12249","type":"journal-article","created":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T18:29:36Z","timestamp":1420828176000},"page":"502-509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Presumed primary ocular lymphangiosarcoma with metastasis in a miniature horse"],"prefix":"10.1111","volume":"18","author":[{"given":"Joseph C.","family":"Gerding","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine North Carolina State University Raleigh NC 27606 USA"},{"name":"North Carolina State University Raleigh NC 27606 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian C.","family":"Gilger","sequence":"additional","affiliation":[{"name":"Department of 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