{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:10:04Z","timestamp":1747613404526,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,10]],"date-time":"2015-02-10T00:00:00Z","timestamp":1423526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the effect of once daily topical 0.3% naltrexone (<jats:styled-content style=\"fixed-case\">NTX<\/jats:styled-content>) on tear production, tear film breakup time (TFBUT), and corneal sensitivity in dogs with uncontrolled keratoconjunctivitis sicca (<jats:styled-content style=\"fixed-case\">KCS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals studied<\/jats:title><jats:p>Sixteen dogs with uncontrolled<jats:styled-content style=\"fixed-case\">KCS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>A randomized placebo\u2010controlled trial was performed in 16 dogs with topical 0.3%<jats:styled-content style=\"fixed-case\">NTX<\/jats:styled-content>once daily or topical saline solution drops once daily. A baseline was obtained at week 0 for tear production (Schirmer tear test 1 and 2\u2014<jats:styled-content style=\"fixed-case\">STT<\/jats:styled-content>1,<jats:styled-content style=\"fixed-case\">STT<\/jats:styled-content>2),<jats:styled-content style=\"fixed-case\">TFBUT<\/jats:styled-content>, and corneal sensitivity.<jats:styled-content style=\"fixed-case\">STT<\/jats:styled-content>1,<jats:styled-content style=\"fixed-case\">STT<\/jats:styled-content>2, and<jats:styled-content style=\"fixed-case\">TFBUT<\/jats:styled-content>were then subsequently measured at weeks 1, 2, and 4 while on<jats:styled-content style=\"fixed-case\">NTX<\/jats:styled-content>or saline drops. Corneal sensitivity measures were repeated at week 4. The drops were subsequently discontinued and all parameters rechecked at week 5.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no statistically significant difference in tear parameters or corneal sensitivity between the<jats:styled-content style=\"fixed-case\">NTX<\/jats:styled-content>\u2010treated and the saline\u2010treated groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Topical 0.3%<jats:styled-content style=\"fixed-case\">NTX<\/jats:styled-content>given as a once daily dose over 4\u00a0weeks did not alter tear production, tear film stability, or corneal sensitivity in dogs with uncontrolled KCS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12255","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T19:33:48Z","timestamp":1423769628000},"page":"497-501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of once daily topical 0.3% naltrexone on tear parameters and corneal sensitivity in dogs with uncontrolled keratoconjunctivitis sicca: a double\u2010masked randomized placebo\u2010controlled clinical trial"],"prefix":"10.1111","volume":"18","author":[{"given":"Thomas","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences C247 Veterinary Medical Center University of Tennessee Knoxville TN 37996 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia C.","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine and Biomedical Sciences Colorado State University 300 W. 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