{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:30:37Z","timestamp":1761863437433,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T00:00:00Z","timestamp":1424131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the absorption of gentamicin into the plasma after an intravitreal injection in dogs and to report the success rate of this procedure in lowering the intraocular pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Twenty\u2010four client\u2010owned dogs with chronic, end\u2010stage glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>Dogs received a unilateral (22) or bilateral (2) intravitreal injection of 25\u201340\u00a0mg of gentamicin (mean\u00a0\u00b1\u00a0SD dose 2.57\u00a0\u00b1\u00a01.65\u00a0mg\/kg and range 0.61\u20137.50\u00a0mg\/kg) and 1\u00a0mg of dexamethasone per eye. Blood samples were collected at various time points following the intravitreal injection. Plasma concentrations of gentamicin were determined by liquid chromatography and mass spectrometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The total plasma concentration of gentamicin ranged from 0.21 to 9.71\u00a0\u03bcg\/mL (mean\u00a0\u00b1\u00a0SD 2.15\u00a0\u00b1\u00a02.03). The mean gentamicin<jats:italic>C<\/jats:italic><jats:sub>MAX<\/jats:sub>was 2.29\u00a0\u03bcg\/mL at 2.54\u00a0h with a terminal half\u2010life of 9.8\u00a0h. The success rate of the chemical ablation procedure was 86.4% (19\/22 eyes) in dogs that had at least 1\u00a0month of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intravitreal injection of gentamicin in eyes with chronic glaucoma resulted in detectable plasma levels in dogs and was successful in lowering the intraocular pressure in 86.4% of the eyes after the first procedure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12258","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T09:03:19Z","timestamp":1424163799000},"page":"57-62","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Measurement of plasma gentamicin concentrations postchemical ciliary body ablation in dogs with chronic glaucoma"],"prefix":"10.1111","volume":"19","author":[{"given":"Amy J.","family":"Rankin","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Kansas State University Manhattan KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick","family":"Lanuza","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Kansas State University Manhattan KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Butch","family":"KuKanich","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Physiology Kansas State University Manhattan KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William C.","family":"Crumley","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies University of Pennsylvania Philadelphia PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D.","family":"Pucket","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Oklahoma State University Stillwater OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel A.","family":"Allbaugh","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Iowa State University Ames IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica M.","family":"Meekins","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Kansas State University Manhattan KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,17]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"113","article-title":"Intraocular gentamicin and glaucoma: a retrospective study of 60 dog and cat eyes (1985\u20131993)","volume":"4","author":"Bingaman D","year":"1994","journal-title":"Veterinary & Comparative Ophthalmology"},{"key":"e_1_2_5_3_1","first-page":"319","article-title":"Indications for and complications of pharmacological ablation of the ciliary body for the treatment of chronic glaucoma in the dog","volume":"22","author":"Moller I","year":"1986","journal-title":"Journal of the American Animal Hospital Association"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/svms.2001.22809"},{"key":"e_1_2_5_5_1","unstructured":"VainisiS SchmidtG WestCet\u00a0al. editors.Intraocular gentamicin for the control of endophthalmitis and glaucoma in animals. 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