{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:08:24Z","timestamp":1761581304073},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T00:00:00Z","timestamp":1430179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 15\u2010month\u2010old spayed female ferret (<jats:italic>Mustela putorius furo)<\/jats:italic> presented for lethargy and weight loss of 2\u00a0weeks duration. Upon physical examination, a 2\u2010mm\u2010diameter focal area of opacity was noted in the left cornea. In addition, the ferret was quiet, in poor body condition, and dehydrated. A complete blood count and plasma biochemistry revealed a severe nonregenerative anemia, azotemia, hyperproteinemia, hypoalbuminemia, and mild hyperphosphatemia and hyperchloremia. Urinalysis revealed hyposthenuria. Whole body radiographs showed multifocal thoracic nodular disease, splenomegaly, and renomegaly. Abdominal ultrasonography confirmed bilaterally enlarged kidneys, hypoechoic liver and spleen, and a caudal abdominal hypoechoic mobile nodule. The ferret was humanely euthanized, and a postmortem examination with subsequent histopathology showed multifocal necrotizing pyogranulomas in the lung, spleen, kidneys, mesenteric lymph nodes, and serosa of the duodenum. Pyogranulomatous panophthalmitis was diagnosed in the left eye. The multisystemic granulomatous lesions were suggestive of ferret systemic coronavirus (<jats:styled-content style=\"fixed-case\">FRSCV<\/jats:styled-content>). The presence of coronavirus in the left eye was confirmed by positive immunohistochemistry. Reverse transcriptase polymerase chain reaction (<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>) on formalin fixed paraffin embedded tissue from the lung, spleen, and kidney was negative for <jats:styled-content style=\"fixed-case\">FRSCV<\/jats:styled-content> and positive for ferret enteric coronavirus (<jats:styled-content style=\"fixed-case\">FRECV<\/jats:styled-content>). Systemic coronavirus disease in ferrets closely resembles feline infectious peritonitis (<jats:styled-content style=\"fixed-case\">FIP<\/jats:styled-content>) in domestic cats, which can manifest with anterior uveitis, chorioretinitis, optic neuritis, and retinal detachment. To the authors\u2019 knowledge, this is the first report of ocular lesions in a ferret with systemic coronavirus disease, suggesting that ferrets presented with similar ocular lesions should also be evaluated for evidence of coronavirus infection.<\/jats:p>","DOI":"10.1111\/vop.12274","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T08:53:17Z","timestamp":1430211197000},"page":"167-171","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Pyogranulomatous panophthalmitis with systemic coronavirus disease in a domestic ferret (<i>Mustela putorius furo)<\/i>"],"prefix":"10.1111","volume":"19","author":[{"given":"Dana M.","family":"Lindemann","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences College of Veterinary Medicine Kansas State University 1800 Dennison Avenue Manhattan Kansas 66506 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