{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T22:42:08Z","timestamp":1769553728868,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,9]],"date-time":"2015-05-09T00:00:00Z","timestamp":1431129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Bullous keratopathy (<jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content>) is a serious corneal condition leading to impaired vision and ocular pain, due to chronic corneal edema and recurrent superficial ulceration. <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> is refractory to conventional therapy. In human patients, corneal collagen cross\u2010linking (<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>) has been used for the treatment of <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> treatment was recently described for canine patients. The aim of this study was to evaluate the clinical and pachymetric effects of accelerated <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> in dogs affected by <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal studied<\/jats:title><jats:p>Eight dogs (10 eyes) with <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> underwent accelerated <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> treatment comprised 30\u00a0min of riboflavin\u2013dextran instillation, followed by 3\u00a0min of <jats:styled-content style=\"fixed-case\">UVA<\/jats:styled-content> irradiation at 30\u00a0mW\/cm\u00b2. Ocular pain, corneal edema, corneal ulceration, and pachymetry were evaluated 7, 14, 30, 90, and 180\u00a0days after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Corneal ulceration and ocular pain were resolved by 1\u00a0week after <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> treatment and did not recur during the 6\u2010month follow\u2010up period. Corneal edema improved in the first 3\u00a0months, but worsened from months 3 to 6. Corneal thickness initially decreased, but returned to baseline by 6\u00a0months post\u2010<jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> is a useful treatment option for <jats:styled-content style=\"fixed-case\">BK<\/jats:styled-content> in dogs, despite the short\u2010lasting effects on corneal thickness. Patient comfort improved rapidly after a single procedure, although <jats:styled-content style=\"fixed-case\">CXL<\/jats:styled-content> did not achieve resolution of corneal edema. Treatment protocols may be refined to produce more durable effects on corneal edema.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12280","type":"journal-article","created":{"date-parts":[[2015,5,9]],"date-time":"2015-05-09T08:23:28Z","timestamp":1431159808000},"page":"250-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Evaluation of accelerated corneal collagen cross\u2010linking for the treatment of bullous keratopathy in eight dogs (10 eyes)"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6199-9063","authenticated-orcid":false,"given":"Frank","family":"Famose","sequence":"first","affiliation":[{"name":"Clinique v\u00e9t\u00e9rinaire Ophtalmologie 42 avenue Servanty Blagnac 31700 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