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Aqueous humor flow rate (<jats:styled-content style=\"fixed-case\">AHF<\/jats:styled-content>) was determined at baseline and at the end of the treatment phase in six normal cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>was significantly lower in treated vs. control eyes of<jats:styled-content style=\"fixed-case\">PCG<\/jats:styled-content>cats, for up to 8\u00a0h following a single latanoprost treatment, and a maximal<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>reduction of 63% occurred in treated eyes at 3\u00a0h. Latanoprost acutely lowered<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>in cats with<jats:styled-content style=\"fixed-case\">PCG<\/jats:styled-content>, but this effect appeared to diminish over 3\u00a0weeks of treatment.<jats:styled-content style=\"fixed-case\">AHF<\/jats:styled-content>was modestly increased in the treated eyes of normal cats after 3\u00a0weeks of latanoprost treatment, although<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>was not significantly affected. Latanoprost caused miosis, with rebound mydriasis at 24\u00a0h posttreatment, in the treated eyes of all cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Further research is needed to determine the suitability and efficacy of latanoprost treatment for long\u2010term<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\u2010lowering in cats with<jats:styled-content style=\"fixed-case\">PCG<\/jats:styled-content>or other forms of glaucoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12292","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T23:46:03Z","timestamp":1437090363000},"page":"13-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of topical latanoprost 0.005% on intraocular pressure and pupil diameter in normal and glaucomatous cats"],"prefix":"10.1111","volume":"19","author":[{"given":"Jessica E.","family":"McDonald","sequence":"first","affiliation":[{"name":"Department of Ophthalmology &amp; Visual Sciences University of Wisconsin \u2010 Madison Madison WI 53792 USA"},{"name":"Department of Surgical Sciences University of Wisconsin \u2010 Madison Madison WI 53706 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Kiland","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology &amp; Visual Sciences University of Wisconsin \u2010 Madison Madison WI 53792 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul L.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology &amp; Visual Sciences University of Wisconsin \u2010 Madison Madison WI 53792 USA"},{"name":"McPherson Eye Research Institute University of Wisconsin \u2010 Madison Madison WI 53706 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellison","family":"Bentley","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences University of Wisconsin \u2010 Madison Madison WI 53706 USA"},{"name":"McPherson Eye Research Institute University of Wisconsin \u2010 Madison Madison WI 53706 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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