{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:57:56Z","timestamp":1770746276059,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T00:00:00Z","timestamp":1435536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Western College of Veterinary Medicine Interprovinicail Undergraduate Student Research Fund","award":["2014"],"award-info":[{"award-number":["2014"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the incidence of iridociliary cysts, pigmentary uveitis (<jats:styled-content style=\"fixed-case\">PU<\/jats:styled-content>)\/pigmentary cystic glaucoma (<jats:styled-content style=\"fixed-case\">PCG<\/jats:styled-content>) in golden retriever dogs in western Canada, the progression of iridociliary cysts to<jats:styled-content style=\"fixed-case\">PU<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PCG<\/jats:styled-content>, and a mode of inheritance for this disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal studied<\/jats:title><jats:p>A total of 830 golden retriever dogs from Alberta, Saskatchewan, and Manitoba from 2004 to 2014 were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Data were compiled from Canine Eye Registry Foundation (<jats:styled-content style=\"fixed-case\">CERF<\/jats:styled-content>) or Orthopedic Foundation for Animals (<jats:styled-content style=\"fixed-case\">OFA<\/jats:styled-content>) records (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>630) and clinical consultations (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>200) for a retrospective assessment of iridociliary cysts,<jats:styled-content style=\"fixed-case\">PU<\/jats:styled-content>, and<jats:styled-content style=\"fixed-case\">PCG<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total incidence of iridociliary cysts and<jats:styled-content style=\"fixed-case\">PU<\/jats:styled-content>from<jats:styled-content style=\"fixed-case\">CERF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">OFA<\/jats:styled-content>data were 4.8% (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>30\/630) and 5.9% (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>37\/630), respectively. Incidence of<jats:styled-content style=\"fixed-case\">PU<\/jats:styled-content>increased with ages &gt;4\u00a0years (12.7%,<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>32\/251). Dogs diagnosed with thin\u2010walled, attached iridociliary cysts had a high risk of being diagnosed with<jats:styled-content style=\"fixed-case\">PU<\/jats:styled-content>or<jats:styled-content style=\"fixed-case\">PCG<\/jats:styled-content>upon re\u2010examination (56.5%,<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>13\/23). No dogs diagnosed with thick\u2010walled, anterior chamber cysts (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>7) developed<jats:styled-content style=\"fixed-case\">PU<\/jats:styled-content>or<jats:styled-content style=\"fixed-case\">PCG<\/jats:styled-content>within the time frame of the study. Data from clinical consultations confirmed that<jats:styled-content style=\"fixed-case\">PU<\/jats:styled-content>carried a poor prognosis for the affected eyes as 44.9% (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>22\/49) of dogs progressed to<jats:styled-content style=\"fixed-case\">PCG<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">PU<\/jats:styled-content>\u2010 and<jats:styled-content style=\"fixed-case\">PCG<\/jats:styled-content>\u2010affected dogs followed a familial pattern and there was an association with thin\u2010walled iridociliary cysts. Pedigree analysis suggested an autosomal dominant mode of inheritance with partial penetrance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thin\u2010walled iridociliary cysts are associated with<jats:styled-content style=\"fixed-case\">PU<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">PCG<\/jats:styled-content>. All breeding golden retriever dogs should be examined annually by an ophthalmologist. The incidence of this disorder is higher in western Canada than previous reports in North America.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12293","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T05:49:15Z","timestamp":1435556955000},"page":"237-244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Golden retriever cystic uveal disease: a longitudinal study of iridociliary cysts, pigmentary uveitis, and pigmentary\/cystic glaucoma over a decade in western Canada"],"prefix":"10.1111","volume":"19","author":[{"given":"Vanessa L.","family":"Holly","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences Western College of Veterinary Medicine University of Saskatchewan Saskatoon SK Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynne S.","family":"Sandmeyer","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences Western College of Veterinary Medicine University of Saskatchewan Saskatoon SK Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca S.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences Western College of Veterinary Medicine University of Saskatchewan Saskatoon SK Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Verges","sequence":"additional","affiliation":[{"name":"Calgary AB T3B 3S4 Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce H.","family":"Grahn","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences Western College of Veterinary Medicine University of Saskatchewan Saskatoon SK Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1998.00018.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2000.00151.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2009.00732.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.243.9.1298"},{"key":"e_1_2_8_6_1","first-page":"800","article-title":"Diagnostic ophthalmology","volume":"53","author":"Grahn BH","year":"2012","journal-title":"The Canadian Veterinary Journal La Revue Veterinaire Canadienne"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.2460\/javma.1993.203.04.0545","article-title":"Uveal cysts in dogs: 28 cases (1989\u20131991)","volume":"203","author":"Corcoran KA","year":"1993","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1998.00007.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12000"},{"key":"e_1_2_8_10_1","first-page":"321","article-title":"Diagnostic ophthalmology","volume":"53","author":"Grahn BH","year":"2012","journal-title":"The Canadian Veterinary Journal La Revue Veterinaire Canadienne"},{"key":"e_1_2_8_11_1","first-page":"569","article-title":"Diagnostic ophthalmology. 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