{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T21:40:02Z","timestamp":1748641202279,"version":"3.41.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T00:00:00Z","timestamp":1443484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the effects of short\u2010term oral administration of trimethoprim\u2010sulfamethoxazole on tear production in clinically normal guinea pigs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal studied<\/jats:title><jats:p>Thirty\u2010two healthy adult Abyssinian guinea pigs were used in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>One day before the start of the trial, the pretreatment baseline phenol red thread test (<jats:styled-content style=\"fixed-case\">PRTT<\/jats:styled-content>) values were recorded. Sixteen guinea pigs in the treated group received 25 mg\/kg trimethoprim\u2010sulfamethoxazole orally twice a day for 14 days. The other sixteen guinea pigs were used as untreated controls and received a placebo during the study. All the ophthalmic tests were performed without chemical restraint.<jats:styled-content style=\"fixed-case\">PRTT<\/jats:styled-content>values were evaluated in both eyes of all the guinea pigs using a commercial<jats:styled-content style=\"fixed-case\">PRTT<\/jats:styled-content>strip of a single lot number on days 0 (baseline), 15, and 21 after starting the trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pretreatment baseline mean \u00b1<jats:styled-content style=\"fixed-case\">SD PRTT<\/jats:styled-content>values for the treatment and control groups were 11.12 \u00b1 3.82 mm\/15 s and 11.93 \u00b1 2.73 mm\/15 s, respectively. After 14 days of drug administration, the mean \u00b1<jats:styled-content style=\"fixed-case\">SD PRTT<\/jats:styled-content>values for the treatment and control groups were 10.87 \u00b1 3.11 mm\/15 s and 13.00 \u00b1 2.47 mm\/15 s, respectively. On Day 21, the mean \u00b1<jats:styled-content style=\"fixed-case\">SD PRTT<\/jats:styled-content>values for the treatment and control groups were 12.62 \u00b1 4.05 mm\/15 s and 12.87 \u00b1 2.99 mm\/15 s, respectively. Significant decreases in the<jats:styled-content style=\"fixed-case\">PRTT<\/jats:styled-content>values, compared with the pretreatment baseline values, were not observed in the treatment group on Day 15 (<jats:italic>P<\/jats:italic>= 0.14) and Day 21 (<jats:italic>P<\/jats:italic>= 0.31).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Trimethoprim\u2010sulfamethoxazole did not decrease tear production in the guinea pigs in this study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12317","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T08:37:29Z","timestamp":1443515849000},"page":"414-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of oral administration of trimethoprim\u2010sulfamethoxazole on tear production in clinically normal guinea 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