{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:00:26Z","timestamp":1773280826655,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T00:00:00Z","timestamp":1448841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"Abstract<\/jats:title>Purpose<\/jats:title>Prostaglandin analogs contribute to blood\u2010aqueous barrier breakdown and may exacerbate uveitis. As these analogs induce de novo synthesis of endogenous prostaglandins, their therapeutic, hypotensive effect could potentially be inhibited by anti\u2010inflammatory treatment. We therefore evaluated whether topical 1% prednisolone acetate alters the effects of 0.005% latanoprost on pupil diameter (PD<\/jats:styled-content>) and intraocular pressure (IOP<\/jats:styled-content>).<\/jats:p><\/jats:sec>Animals studied<\/jats:title>Ten healthy Labrador retriever dogs from the Israel Guide Dog Center for the Blind.<\/jats:p><\/jats:sec>Methods<\/jats:title>Pupil diameter and IOP<\/jats:styled-content> were measured hourly, 8 AM<\/jats:styled-content>\u20134 PM<\/jats:styled-content>, with the right and left eyes serving as control (CE<\/jats:styled-content>) and treated (TE<\/jats:styled-content>) eyes, respectively. Measurements were conducted during four sessions: (1) without treatment (n<\/jats:italic> = 10), (2) following latanoprost treatment (n<\/jats:italic> = 10) at 8 AM<\/jats:styled-content>, (3) following prednisolone treatment (n<\/jats:italic> = 7) at 8 AM<\/jats:styled-content>, and (4) bilateral latanoprost treatment at 8 AM<\/jats:styled-content>, prednisolone treatment in TE<\/jats:styled-content> at 11 AM<\/jats:styled-content> (n<\/jats:italic> = 8). The different number of dogs in sessions 3 and 4 is because some dogs were matched with their new owners earlier than expected.<\/jats:p><\/jats:sec>Results<\/jats:title>Pupil diameters were not affected by the addition of prednisolone and, at 4 PM<\/jats:styled-content>, were 3.82 \u00b1 0.47 and 3.97 \u00b1 0.36 mm in TE<\/jats:styled-content> and CE<\/jats:styled-content>, respectively (P<\/jats:italic> = 0.175, Wilcoxon). IOP<\/jats:styled-content>s were not affected by the addition of prednisolone and, at 4 PM<\/jats:styled-content>, were 9.0 \u00b1 0.8 and 9.3 \u00b1 0.8 mm Hg in TE<\/jats:styled-content> and CE<\/jats:styled-content>, respectively (P<\/jats:italic> = 0.339, Wilcoxon).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Prednisolone did not alter latanoprost's miotic and hypotensive effects in normal dogs during this study period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12329","type":"journal-article","created":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T04:02:42Z","timestamp":1448942562000},"page":"473-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The effects of 1% prednisolone acetate on pupil diameter and intraocular pressure in healthy dogs treated with 0.005% latanoprost"],"prefix":"10.1111","volume":"19","author":[{"given":"Nili","family":"Kahane","sequence":"first","affiliation":[{"name":"Koret School of Veterinary Medicine The Hebrew University of Jerusalem Rehovot 7610001 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tali","family":"Bdolah\u2010Abram","sequence":"additional","affiliation":[{"name":"Koret School of Veterinary Medicine The Hebrew University of Jerusalem Rehovot 7610001 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilli","family":"Raskansky","sequence":"additional","affiliation":[{"name":"Koret School of Veterinary Medicine The Hebrew University of Jerusalem Rehovot 7610001 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Ofri","sequence":"additional","affiliation":[{"name":"Koret School of Veterinary Medicine The Hebrew University of Jerusalem Rehovot 7610001 Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2011.00958.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1996.0119"},{"key":"e_1_2_6_4_1","first-page":"1113","volume-title":"Veterinary Ophthalmology","author":"Gelatt KN","year":"2013"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.8.1165"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2008.08.010"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-1281"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.080895"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5216.2001.00202.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2010.00832.x"},{"key":"e_1_2_6_11_1","unstructured":"WardDA.Effects of latanoprost of aqueous humor flow rates in normal dogs (abstract). 36th Annual Meeting of the American College of Veterinary Ophthalmologists2005;15."},{"key":"e_1_2_6_12_1","first-page":"407","volume-title":"Veterinary Ophthalmology","author":"Rankin A","year":"2013"},{"key":"e_1_2_6_13_1","first-page":"42","volume-title":"Slatter's Fundamentals of Veterinary Ophthalmology","author":"Maggs DJ","year":"2013"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2005.00399.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12069"},{"key":"e_1_2_6_16_1","unstructured":"GilmourMA LehenbauerTW.Effect of dexamethasone sodium phosphate 0.1% on intraocular pressure in normal dogs treated with latanoprost 0.005% (abstract). 40th Annual Meeting of the American College of Veterinary Ophthalmologists2009;193."},{"key":"e_1_2_6_17_1","unstructured":"PirieCG MaggioF MarandaLet al.Combined effect of topical Prednisolone and Latanoprost on normal canine eyes. 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