{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:51:17Z","timestamp":1785883877652,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T00:00:00Z","timestamp":1451260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002551","name":"Seoul National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002551","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The goal of this study was to evaluate the effects of topical latanoprost on the anterior segment and ciliary body using ultrasound biomicroscopy (UBM) in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals studied<\/jats:title><jats:p>This study included six eyes of six clinically normal beagles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>UBM scans were performed on six sedated dogs before and 2 h after topical latanoprost instillation. From the next day on, latanoprost was topically applied twice daily for 7 days. After 1 week of instillation, the UBM scans were repeated. The ciliary body thickness (CBT) and the anterior segment parameters, including the iridocorneal angle (ICA), the width of the ciliary cleft (CC) entry, the length of the CC, and the width of the mid\u2010CC, were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The topical latanoprost decreased the ICA and CC entry width and increased the mid\u2010CC width without any significant alterations in the CC length. There were time\u2010dependent alterations in the CBT: a reduction in the CBT after 2 h of instillation and rebound thickening after 1 week of instillation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The topical latanoprost widened the ciliary cleft despite the narrowing of the ICA and CC entry. Time\u2010dependent alterations in the CBT were demonstrated by the UBM and might be a reflection of the mechanism of the uveoscleral outflow enhancement induced by the topical latanoprost.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12339","type":"journal-article","created":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T11:52:49Z","timestamp":1451303569000},"page":"498-503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Ultrasound biomicroscopic study of the effects of topical latanoprost on the anterior segment and ciliary body thickness in dogs"],"prefix":"10.1111","volume":"19","author":[{"given":"Sangwan","family":"Park","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University 1 Gwanak\u2010ro Gwanak\u2010gu Seoul 151\u2010742 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonmi","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University 1 Gwanak\u2010ro Gwanak\u2010gu Seoul 151\u2010742 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Euiri","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University 1 Gwanak\u2010ro Gwanak\u2010gu Seoul 151\u2010742 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyoon","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University 1 Gwanak\u2010ro Gwanak\u2010gu Seoul 151\u2010742 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunjin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University 1 Gwanak\u2010ro Gwanak\u2010gu Seoul 151\u2010742 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaegook","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University 1 Gwanak\u2010ro Gwanak\u2010gu Seoul 151\u2010742 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangmoon","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University 1 Gwanak\u2010ro Gwanak\u2010gu Seoul 151\u2010742 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,28]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"247","volume-title":"Slatter's Fundamentals of Veterinary Ophthalmology","author":"Miller PE","year":"2013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2011.00970.x"},{"key":"e_1_2_6_4_1","first-page":"1050","volume-title":"Veterinary Ophthalmology","author":"Plummer CE","year":"2013"},{"key":"e_1_2_6_5_1","unstructured":"WardD.Effects of latanoprost on aqueous humor flow rate in normal dogs. 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