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One eye per cat was randomly assigned for treatment twice daily with<jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content>; balanced salt solution (<jats:styled-content style=\"fixed-case\">BSS<\/jats:styled-content>) applied to the contralateral eye served as a control. Differences between eyes and between weeks of the study period were calculated for each cat. A positive response to<jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content>was defined as a consistent &gt;15% or &gt;25% higher<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>in the treated relative to control eye in normal and<jats:styled-content style=\"fixed-case\">FCG<\/jats:styled-content>cats, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 8 of 11<jats:styled-content style=\"fixed-case\">FCG<\/jats:styled-content>cats responded to topical<jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content>after 1\u20135 weeks of treatment with an increase in<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>relative to the untreated eye (maximum<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>discrepancy of 56 mmHg). Two of five normal cats responded to topical<jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content>with an appreciable, but clinically unimportant increase in<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>in the treated eye (maximum<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>discrepancy of 6.4 mmHg).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data indicate that the incidence of steroid\u2010induced<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>elevation in cats is lower than that of previously published feline studies. Cats with preexisting compromise in aqueous humor outflow may show a greater, clinically relevant response to topical<jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content>than normal cats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12355","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T08:40:26Z","timestamp":1455525626000},"page":"69-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effects of topical corticosteroid administration on intraocular pressure in normal and glaucomatous cats"],"prefix":"10.1111","volume":"19","author":[{"given":"Allyson A.","family":"Gosling","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences University of Wisconsin\u2010Madison Madison WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Kiland","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology 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