{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T15:09:24Z","timestamp":1781708964698,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T00:00:00Z","timestamp":1455580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether any association exists between the onset of feline acute bullous keratopathy (<jats:styled-content style=\"fixed-case\">ABK<\/jats:styled-content>) and administration of systemic corticosteroid or immunosuppressive therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals studied<\/jats:title><jats:p>Medical records of cats diagnosed with <jats:styled-content style=\"fixed-case\">ABK<\/jats:styled-content> between the years of 2000 and 2008 were retrospectively reviewed. Breed, age at diagnosis, weight, systemic disease status, eye affected, ophthalmic examination findings, systemic and topical therapy instituted, dosage and duration of therapy, visual outcome and histopathological analyses were recorded in cases meeting the inclusion criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 12 cats of a surveyed population of 70 167 met the inclusion criteria with 17\/24 eyes affected by <jats:styled-content style=\"fixed-case\">ABK<\/jats:styled-content>. Medical and\/or surgical therapy was utilized for management of <jats:styled-content style=\"fixed-case\">ABK<\/jats:styled-content> with 13\/17 eyes remaining sighted at the time of last follow\u2010up. In a subset of cases corneal cytology, aerobic bacterial culture, <jats:styled-content style=\"fixed-case\">FHV<\/jats:styled-content>\u20101 <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>, virus isolation and\/or histopathology were performed; no infectious organisms were identified. A rupture in Descemet's membrane of the cornea was identified histologically in two globes. A total of 10 of 12 cats had been previously diagnosed with ongoing systemic disease. A total of 10 of 12 cats were receiving systemic therapy, and a significant association (<jats:italic>P<\/jats:italic> &lt; 0.001) was noted between systemic administration of corticosteroids and\/or cyclosporine A and the development of <jats:styled-content style=\"fixed-case\">ABK<\/jats:styled-content>. A total of 8 of 10 cats were administered oral prednisolone at doses between 1\u20132 mg\/kg every 12\u201324 h. A total of 5 of 8 cats receiving oral prednisolone were concurrently administered oral cyclosporine at doses of 1.5\u20137 mg\/kg every 12\u201324 h. Systemic cyclosporine therapy was found to be a significant risk factor (<jats:italic>P<\/jats:italic> &lt; 0.001) for <jats:styled-content style=\"fixed-case\">ABK<\/jats:styled-content> development, while systemic prednisolone was not significant (<jats:italic>P<\/jats:italic> = 0.10).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Systemic cyclosporine administration appears to be a risk factor for development of <jats:styled-content style=\"fixed-case\">ABK<\/jats:styled-content> in the population of cats studied.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12367","type":"journal-article","created":{"date-parts":[[2016,2,16]],"date-time":"2016-02-16T09:16:05Z","timestamp":1455614165000},"page":"77-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["An association between systemic cyclosporine administration and development of acute bullous keratopathy in cats"],"prefix":"10.1111","volume":"19","author":[{"suffix":"Jr.","given":"Kenneth E.","family":"Pierce","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences Michigan State University East Lansing MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4237-0371","authenticated-orcid":false,"given":"David A.","family":"Wilkie","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences The Ohio State University Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne J.","family":"Gemensky\u2010Metzler","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences The Ohio State University Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul G.","family":"Curran","sequence":"additional","affiliation":[{"name":"Center for Statistical Training and Consulting Michigan State University East Lansing MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy M.","family":"Townsend","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Purdue University West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon M.","family":"Petersen\u2010Jones","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences Michigan State University East Lansing MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua T.","family":"Bartoe","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences Michigan State University East Lansing MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,16]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"66","article-title":"Acute bullous keratopathy in the cat","volume":"4","author":"Glover TL","year":"1994","journal-title":"Vet Comp Ophthalmol"},{"key":"e_1_2_5_3_1","first-page":"187","article-title":"Acute bullous keratopathy in a domestic shorthair","volume":"49","author":"Pattullo K","year":"2008","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_5_4_1","first-page":"181","article-title":"Bullous keratopathy: a latent complication of chronic corneal disease","volume":"69","author":"Rosenthal JJ","year":"1974","journal-title":"Vet Med Small Anim Clin"},{"key":"e_1_2_5_5_1","first-page":"643","article-title":"Keratopathia bullosa in a Persian cat","volume":"51","author":"Auer B","year":"2006","journal-title":"Kleintierpraxis"},{"key":"e_1_2_5_6_1","first-page":"241","volume-title":"Ophthalmic diseases in veterinary medicine","author":"Martin C","year":"2005"},{"key":"e_1_2_5_7_1","unstructured":"EvansC WilkieD Lara\u2010GarciaAet al.Bilateral feline acute bullous keratopathy and immunosuppressive drugs. 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