{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:34:39Z","timestamp":1790112879893,"version":"4.0.1"},"reference-count":107,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T00:00:00Z","timestamp":1461024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08 EY021142"],"award-info":[{"award-number":["K08 EY021142"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Feline herpesvirus type 1 (<jats:styled-content style=\"fixed-case\">FHV<\/jats:styled-content>\u20101) is a common and important cause of ocular surface disease, dermatitis, respiratory disease, and potentially intraocular disease in cats. Many antiviral drugs developed for the treatment of humans infected with herpesviruses have been used to treat cats infected with<jats:styled-content style=\"fixed-case\">FHV<\/jats:styled-content>\u20101. Translational use of drugs in this manner ideally requires methodical investigation of their<jats:italic>in vitro<\/jats:italic>efficacy against<jats:styled-content style=\"fixed-case\">FHV<\/jats:styled-content>\u20101 followed by pharmacokinetic and safety trials in normal cats. Subsequently, placebo\u2010controlled efficacy studies in experimentally inoculated animals should be performed followed, finally, by carefully designed and monitored clinical trials in client\u2010owned animals. This review is intended to provide a concise overview of the available literature regarding the efficacy of antiviral drugs and other compounds with proven or putative activity against<jats:styled-content style=\"fixed-case\">FHV<\/jats:styled-content>\u20101, as well as a discussion of their safety in cats.<\/jats:p>","DOI":"10.1111\/vop.12375","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T06:25:35Z","timestamp":1461047135000},"page":"119-130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["A review of antiviral drugs and other compounds with activity against feline herpesvirus type 1"],"prefix":"10.1111","volume":"19","author":[{"given":"Sara M.","family":"Thomasy","sequence":"first","affiliation":[{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine University of California\u2010Davis Davis CA 95616 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Maggs","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences School of Veterinary Medicine University of California\u2010Davis Davis CA 95616 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctsap.2004.12.013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2460\/javma.1995.207.05.0599","article-title":"Treatment of cats with ocular disease attributable to herpesvirus infection: 17 cases (1983\u20131993)","volume":"207","author":"Stiles J","year":"1995","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_6_4_1","article-title":"Oral administration of famciclovir for treatment of spontaneous ocular, respiratory or dermatologic disease attributed to feline herpesvirus type\u20101: a retrospective review in 59 client\u2010owned cats","author":"Thomasy SM","year":"2016","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro975"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2014.06.003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.47.8.449"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(80)35273-1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S0090-9556(25)05672-7","article-title":"Studies of 9\u2010beta\u2010D\u2010arabinofuranosyladenine in man","volume":"1","author":"LePage GA","year":"1973","journal-title":"Drug Metabolism and Disposition"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/131.3.225"},{"key":"e_1_2_6_11_1","first-page":"25","article-title":"Adenine arabinoside therapy in corneal stromal disease and iritis due to herpes simplex","volume":"6","author":"Brightbill FS","year":"1974","journal-title":"Annals of Ophthalmology"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/134.1.75"},{"key":"e_1_2_6_13_1","first-page":"302","article-title":"Adenine arabinoside effect on experimental idoxuridine\u2010resistant herpes simplex infection","volume":"13","author":"Nesburn AB","year":"1974","journal-title":"Investigative Ophthalmology"},{"key":"e_1_2_6_14_1","first-page":"1171","article-title":"Treatment of herpes simplex keratitis with idoxuridine and vidarabine: a double\u2010blind study","volume":"10","author":"Chin GN","year":"1978","journal-title":"Annals of Ophthalmology"},{"key":"e_1_2_6_15_1","first-page":"1093","article-title":"The corneal penetration of trifluorothymidine, adenine arabinoside, and idoxuridine: a comparative study","volume":"16","author":"O'Brien WJ","year":"1977","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S0026-895X(25)09608-7","article-title":"Identification of enzymes catalyzing two\u2010step phosphorylation of cidofovir and the effect of cytomegalovirus infection on their activities in host cells","volume":"50","author":"Cihlar T","year":"1996","journal-title":"Molecular Pharmacology"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(90)90271-R"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-5853-4_28"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.12.1839"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.116.6.777"},{"key":"e_1_2_6_21_1","first-page":"378","article-title":"Comparative antiviral efficacies of cidofovir, trifluridine, and acyclovir in the HSV\u20101 rabbit keratitis model","volume":"40","author":"Romanowski EG","year":"1999","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(91)90057-X"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.69.2.289"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)01569-6"},{"key":"e_1_2_6_25_1","first-page":"4135","article-title":"Topical HPMPC inhibits adenovirus type 5 in the New Zealand rabbit ocular replication model","volume":"35","author":"Gordon YJ","year":"1994","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2004.65.399"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2010.00784.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-48-2-451"},{"key":"e_1_2_6_29_1","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1177\/106002809603000911","article-title":"The past as prelude to the future: history, status, and future of antiviral drugs","volume":"30","author":"Whitley RJ","year":"1996","journal-title":"Annals of Pharmacotherapy"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2007.10.015"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-007-0021-6"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713680490504849"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1996.tb00087.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.157.9.254"},{"key":"e_1_2_6_35_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0090-9556(25)08306-0","article-title":"Metabolic fate and pharmacokinetics of the acyclovir prodrug valaciclovir in cynomolgus monkeys","volume":"22","author":"Miranda P","year":"1994","journal-title":"Drug Metabolism and Disposition"},{"key":"e_1_2_6_36_1","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.2460\/ajvr.1997.58.10.1141","article-title":"Effects of valacyclovir in cats infected with feline herpesvirus 1","volume":"58","author":"Nasisse MP","year":"1997","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.22.1.55"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.17135"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703770"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090020077027"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S58242"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/00912709922008452"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.22.13.1124.33527"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12094"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2008.05.018"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.72.1.85"},{"key":"e_1_2_6_47_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0090-9556(25)06527-4","article-title":"Role of aldehyde oxidase in the in vitro conversion of famciclovir to penciclovir in human liver","volume":"23","author":"Clarke SE","year":"1995","journal-title":"Drug Metabolism and Disposition"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.10.1765"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498259409045899"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx049737i"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.77.8.833"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2008.11.012"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.73.7.1092"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2011.00984.x"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.11.1252"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1994.51"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(1980)5:4<309::AID-JMV1890050407>3.0.CO;2-L"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2533"},{"key":"e_1_2_6_59_1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.2460\/ajvr.1989.50.01.158","article-title":"In vitro susceptibility of feline herpesvirus\u20101 to vidarabine, idoxuridine, trifluridine, acyclovir, or bromovinyldeoxyuridine","volume":"50","author":"Nasisse MP","year":"1989","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-2-13"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2000.61.1474"},{"key":"e_1_2_6_62_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1128\/jb.87.3.609-613.1964","article-title":"Amino acid requirements of herpes simplex virus in human cells","volume":"87","author":"Tankersley RW","year":"1964","journal-title":"Journal of Bacteriology"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1159\/000237979"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(70)90382-X"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-015-0594-3"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.75.6.572"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.2460\/AJVR.2002.63.99"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2003.64.37"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2008.03.004"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.8.2042S"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2006.08.005"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.70.11.1391"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2005.66.210"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.67.8.1406"},{"key":"e_1_2_6_75_1","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.2460\/ajvr.1989.50.10.1672","article-title":"Synergistic antiviral activities of acyclovir and recombinant human leukocyte (alpha) interferon on feline herpesvirus replication","volume":"50","author":"Weiss RC","year":"1989","journal-title":"American Journal of Veterinary Research"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(85)80031-0"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2007.00550.x"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.120.16.391"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2014.09.030"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X15596199"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.74.2.281"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2012.09.025"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1245"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2011.09.015"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200101150-00031"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.9.1010"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2003.00301.x"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.70.8.1018"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.71.6.655"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.74.2.243"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2008.12.006"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.70.3.394"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1999.00082.x"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.4.1761-1769.2001"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2014.11.005"},{"key":"e_1_2_6_96_1","volume-title":"The American Academy of Ophthalmology Clinical Guidelines","author":"White ML"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.10.034"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01967066"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.8.6.643"},{"key":"e_1_2_6_100_1","first-page":"331","article-title":"[Experimental studies of 9\u2010(1, 3\u2010dihydroxy\u20102\u2010propoxymethyl)\u2010guanine(DHPG) against herpes simplex virus]","volume":"24","author":"Chen ZJ","year":"1989","journal-title":"Yao Xue Xue Bao"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.8.1238"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(87)80004-9"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(84)90026-3"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(85)90011-7"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2005.66.217"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00127a010"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.2195"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/12.suppl_B.19"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvop.12375","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.12375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T20:14:40Z","timestamp":1748895280000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.12375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,19]]},"references-count":107,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/vop.12375"],"URL":"https:\/\/doi.org\/10.1111\/vop.12375","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,19]]},"assertion":[{"value":"2016-04-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}