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In a second treatment phase, a single drop of timolol was administered at 8 pm for 3 nights and<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>, and<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>were measured, as above, beginning at 8 am on day 4. Slit\u2010lamp examinations were conducted prior to and after treatment phases. Comparisons of mean<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>, and<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>were made at each time point and between treated and untreated eyes by repeated\u2010measures<jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content>and Tukey\u2013Kramer post hoc test, with<jats:italic>P<\/jats:italic>&lt; 0.05 considered significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Timolol maleate 0.5%<jats:styled-content style=\"fixed-case\">GFS<\/jats:styled-content>had an inconsistent effect on<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>, with maximum<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\u2010lowering effect (mean = 5.6 mmHg, 17.4%) observed 6 h post\u2010treatment in<jats:styled-content style=\"fixed-case\">FCG<\/jats:styled-content>. The drug caused significant miosis (from 4 to 8 h post\u2010treatment), but had no effect on<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Once\u2010daily application of timolol maleate 0.5%<jats:styled-content style=\"fixed-case\">GFS<\/jats:styled-content>may be of limited clinical benefit in the management of feline congenital glaucoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12376","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T07:20:30Z","timestamp":1458372030000},"page":"91-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of timolol maleate gel\u2010forming solution on intraocular pressure, pupil diameter, and heart rate in normal and glaucomatous cats"],"prefix":"10.1111","volume":"19","author":[{"given":"Julie 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