{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:45:37Z","timestamp":1791499537933,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T00:00:00Z","timestamp":1462924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate effectiveness and safety of debulking and diode laser photocoagulation (DPC) for the treatment of limbal melanoma (LM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Retrospective multi\u2010institutional case series. Medical records of animals diagnosed with LM at the Centro Veterinario Specialistico (CVS) and at the Long Island Veterinary Specialists from 1994 to 2014 were retrieved. Signalment, location, extent of tumors, recurrence rate, and early and late complications were reported. Patient follow\u2010up information was obtained from veterinary ophthalmologists, primary care veterinarians, and where appropriate, owners.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010one eyes of 21 dogs (13 females and 8 males) were included in this study. The dogs' average age was 6 years (range: 7 months\u201311 years). The follow\u2010up period ranged from 1\u2013108 months (median 48 months) after the last DPC procedure. Long\u2010term follow\u2010up was obtained by telephone interviews in 6 of 20 cases and by clinical re\u2010evaluations in 14 of 20 cases. The most common early complications were a moderate anterior uveitis and peripheral corneal edema (21\/21 eyes). Late complications included corneal fibrosis and\/or pigmentation (20\/21). In one case, a severe bullous keratopathy associated with extensive corneal fibrosis was observed (1\/21). One case was blind due to concurrent Sudden Acquired Retinal Degeneration (SARD). However, after surgery 2 of 20 eyes lost vision and one of these was enucleated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Debulking, in addition to diode laser photocoagulation, was technically straightforward to perform, minimally invasive, well tolerated, and highly successful in this case series.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12383","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T12:44:39Z","timestamp":1462970679000},"page":"147-154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The combined use of surgical debulking and diode laser photocoagulation for limbal melanoma treatment: a retrospective study of 21 dogs"],"prefix":"10.1111","volume":"20","author":[{"given":"Valentina","family":"Andreani","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Centro Veterinario Specialistico (CVS) Via Sandro Giovannini 53 Rome 00137 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Guandalini","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Centro Veterinario Specialistico (CVS) Via Sandro Giovannini 53 Rome 00137 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunzio","family":"D'Anna","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Centro Veterinario Specialistico (CVS) Via Sandro Giovannini 53 Rome 00137 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Giudice","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences and Public Health (DiVet) University of Milan via Celoria 10 Milan 20133 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Corvi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Centro Veterinario Specialistico (CVS) Via Sandro 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