{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:50:46Z","timestamp":1790700646931,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T00:00:00Z","timestamp":1463529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To describe the clinical and histopathologic features of glaucoma associated with Descemet's membrane (<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>) detachment in five horses without prior history of intraocular surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals studied<\/jats:title><jats:p>Three Appaloosa horses and two Thoroughbreds were included in this study. The affected horses ranged in age from 16 to 27\u00a0years and presented with severe diffuse corneal edema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Five eyes were enucleated due to intraocular hypertension and\/or chronic corneal ulceration. The enucleated globes were evaluated by the Comparative Ocular Pathology Laboratory of Wisconsin (<jats:styled-content style=\"fixed-case\">COPLOW<\/jats:styled-content>). Each globe was routinely processed for histopathology and analyzed by light microscopy. A histologic diagnosis of glaucoma was reached by demonstrating a loss of optic nerve axonal tissue by measuring neurofilament\u2010immunopositive axons with automated image analysis software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All five horses presented with unilateral severe diffuse corneal edema that had developed between 2 and 16\u00a0weeks prior to enucleation. Intraocular pressures for the affected eyes were between 9 and 87\u00a0mmHg prior to enucleation. Descemet's membrane detachment was identified histopathologically in all five globes (5\/5, 100%). All five eyes had an avascular spindle cell proliferation filling the space between the displaced peripheral<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>and the corneal stroma. Neurofilament immunostaining revealed axonal loss consistent with glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Equine glaucoma may be associated with Descemet's membrane detachment. This detachment and glaucoma is a possible differential diagnosis for severe equine corneal edema. In this case series, an eye with a<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>detachment had a poor prognosis for retention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12388","type":"journal-article","created":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T13:35:28Z","timestamp":1463578528000},"page":"273-279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Glaucoma with Descemet's membrane detachment in five horses"],"prefix":"10.1111","volume":"20","author":[{"given":"Michala de Linde","family":"Henriksen","sequence":"first","affiliation":[{"name":"Comparative Ophthalmology Service Department of Veterinary Clinical Sciences College of Veterinary Medicine University of Minnesota 1352 Boyd Avenue Saint Paul MN 55108 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelle","family":"La Croix","sequence":"additional","affiliation":[{"name":"The Veterinary Medical Center of Long Island 75 Sunrise Highway West Islip NY 11795 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4237-0371","authenticated-orcid":false,"given":"David A.","family":"Wilkie","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Comparative Ophthalmology The Ohio State University 1900 Coffey Road Columbus OH 43210 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Lassaline\u2010Utter","sequence":"additional","affiliation":[{"name":"Department of Radiological and Surgical Sciences University of California\u2010Davis Davis CA 95616 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen R.","family":"Brantman","sequence":"additional","affiliation":[{"name":"Northwest Animal Eye Specialists 13020 NE 85th Street Kirkland WA 98033 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian L.","family":"Beamer","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Global Health Cummings School of Veterinary Medicine Tufts University 200 Westboro Road North Grafton MA 01536 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9960-678X","authenticated-orcid":false,"given":"Leandro B. C.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Comparative Ocular Pathology Laboratory of Wisconsin University of Wisconsin 2015 Linden Dr. #3308 Madison WI 53706 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Dubielzig","sequence":"additional","affiliation":[{"name":"Comparative Ocular Pathology Laboratory of Wisconsin University of Wisconsin 2015 Linden Dr. #3308 Madison WI 53706 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,18]]},"reference":[{"issue":"2","key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.2042-3306.1983.tb04560.x","article-title":"Equine recurrent uveitis","volume":"15","author":"Cook CS","year":"1983","journal-title":"Equine Veterinary Journal"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1638\/02-027"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2009.00740.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.2010.tb05637.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-0846-2.00005-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12199"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-1002"},{"key":"e_1_2_6_9_1","first-page":"163","article-title":"Distinctive morphologic features of the ciliary body in equine recurrent uveitis","volume":"7","author":"Dubielzig RR","year":"1997","journal-title":"Veterinary & Comparative Ophthalmology"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12080"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-2983-7.00009-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S65520"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12102"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-0846-2.00008-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-0846-2.00009-4"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2011.00878.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12234"},{"key":"e_1_2_6_18_1","first-page":"71","volume-title":"Complications of Glaucoma Surgery","author":"Kahook MK","year":"2013"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2005.46.5.719"},{"key":"e_1_2_6_20_1","first-page":"427","article-title":"Detachment of Descemet's membrane","volume":"2","author":"Samuels B","year":"1928","journal-title":"Transactions of the American Ophthalmological Society"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365279"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvop.12388","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvop.12388","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.12388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T12:42:14Z","timestamp":1718541734000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.12388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,18]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/vop.12388"],"URL":"https:\/\/doi.org\/10.1111\/vop.12388","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,18]]},"assertion":[{"value":"2016-05-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}