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A pigment retinopathy has not been identified in horses with neuroaxonal dystrophy\/equine degenerative myeloencephalopathy (<jats:styled-content style=\"fixed-case\">NAD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EDM<\/jats:styled-content>) that affects genetically susceptible young horses with \u03b1\u2010<jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>deficiency. The objective of this report is to describe, for the first time, a pigment retinopathy in a family of \u03b1\u2010<jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>\u2010deficient Warmbloods (<jats:styled-content style=\"fixed-case\">WB<\/jats:styled-content>) with clinically apparent<jats:styled-content style=\"fixed-case\">NAD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EDM<\/jats:styled-content>or<jats:styled-content style=\"fixed-case\">EMND<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals and Procedures<\/jats:title><jats:p>Twenty\u2010five<jats:styled-content style=\"fixed-case\">WB<\/jats:styled-content>horses from one farm underwent complete neurologic and ophthalmic examinations and serum \u03b1\u2010<jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>concentrations were assessed. Two of the most severely ataxic horses were euthanized and postmortem examinations performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Alpha\u2010<jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>deficiency was widespread on this farm (22 of 25 horses). Eleven of 25 horses were clinically normal (age range 2\u201312 years), one had signs of<jats:styled-content style=\"fixed-case\">EMND<\/jats:styled-content>(6 years of age), 10 had signs of ataxia consistent with<jats:styled-content style=\"fixed-case\">NAD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EDM<\/jats:styled-content>(1\u201310 years), and two of these were postmortem confirmed concurrent<jats:styled-content style=\"fixed-case\">NAD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EDM<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">EMND<\/jats:styled-content>. A pigment retinopathy characterized by varying amounts of granular dark pigment in the tapetal retina was observed in four clinically apparent<jats:styled-content style=\"fixed-case\">NAD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EDM<\/jats:styled-content>horses (two postmortem confirmed concurrent<jats:styled-content style=\"fixed-case\">NAD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EDM<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">EMND<\/jats:styled-content>) and one horse with clinical signs of<jats:styled-content style=\"fixed-case\">EMND<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A pigment retinopathy can be present in young \u03b1\u2010<jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>\u2010deficient Warmblood horses with clinical signs of<jats:styled-content style=\"fixed-case\">EMND<\/jats:styled-content>as well as those with signs of<jats:styled-content style=\"fixed-case\">NAD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">EDM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12417","type":"journal-article","created":{"date-parts":[[2016,8,5]],"date-time":"2016-08-05T06:04:10Z","timestamp":1470377050000},"page":"304-309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Pigment retinopathy in warmblood horses with equine degenerative myeloencephalopathy and equine motor neuron disease"],"prefix":"10.1111","volume":"20","author":[{"given":"Carrie J.","family":"Finno","sequence":"first","affiliation":[{"name":"Population Health and Reproduction School of Veterinary Medicine, School of Medicine University of California Davis CA 95616 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"Kaese","sequence":"additional","affiliation":[{"name":"Eye Care for Animals Lees Summit MO 64064 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Miller","sequence":"additional","affiliation":[{"name":"Section of Anatomic Pathology Department of Biomedical Sciences Medicine Cornell University College of Veterinary Ithaca NY 14853 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Gianino","sequence":"additional","affiliation":[{"name":"Population Health and Reproduction School of Veterinary Medicine, School of Medicine University of California Davis CA 95616 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Divers","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Cornell University College of Veterinary Medicine Ithaca NY 14853 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie J.","family":"Valberg","sequence":"additional","affiliation":[{"name":"Large Animal Clinical Sciences College of Veterinary 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