{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:40:00Z","timestamp":1785577200098,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T00:00:00Z","timestamp":1477612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the effect of topical ophthalmic 0.005% latanoprost alone and in combination with 0.1% diclofenac on healthy horses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals studied<\/jats:title><jats:p>Twelve healthy adult horses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>A randomized, masked crossover design was used with horses divided into three groups for once daily treatment in one randomly selected eye. For arm 1 of the study, Group D (<jats:italic>n<\/jats:italic>= 3) received 0.1% diclofenac, Group L (<jats:italic>n<\/jats:italic>= 3) received 0.005% latanoprost, and Group<jats:styled-content style=\"fixed-case\">DL<\/jats:styled-content>(<jats:italic>n<\/jats:italic>= 6) received 0.005% latanoprost and 0.2 ml of 0.1% diclofenac. For arm 2 of the study, horses from Group D and L were placed into Group<jats:styled-content style=\"fixed-case\">DL<\/jats:styled-content>and horses from Group<jats:styled-content style=\"fixed-case\">DL<\/jats:styled-content>were placed into either Group D or L. Evaluations of intraocular pressure (<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>), vertical pupil diameter, aqueous flare, conjunctival hyperemia, epiphora, blepharospasm, and blepharoedema were performed 4 times daily on days 1 and 2 (baseline), days 3 to 7 (arm 1 treatment), days 8 to 11 (washout), days 12 to 16 (arm 2 treatment), and days 17 and 18 (return to baseline).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the treatment period, significant reduction in<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>and vertical pupil diameter occurred in treated eyes of Groups L and<jats:styled-content style=\"fixed-case\">DL<\/jats:styled-content>, but not Group D. These variables did not differ significantly between Groups L and<jats:styled-content style=\"fixed-case\">DL<\/jats:styled-content>. Blepharospasm, blepharoedema, epiphora, and conjunctival hyperemia scores were significantly higher in Group L than in Groups D and<jats:styled-content style=\"fixed-case\">DL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Latanoprost reduced<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>in healthy horses and signs of drug\u2010induced discomfort were mitigated by concurrent use of diclofenac.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12439","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T09:10:27Z","timestamp":1477645827000},"page":"398-404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of topical ophthalmic latanoprost 0.005% solution alone and in combination with diclofenac 0.1% solution in healthy horses: a pilot study"],"prefix":"10.1111","volume":"20","author":[{"given":"Kyle","family":"Tofflemire","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences Iowa State University College of Veterinary Medicine Ames Iowa 50011 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Whitley","sequence":"additional","affiliation":[{"name":"Pathogenesis LLC Gainesville FL 32614 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Allbaugh","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Iowa State University College of Veterinary Medicine Ames Iowa 50011 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Ben\u2010Shlomo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Iowa State University College of Veterinary Medicine Ames Iowa 50011 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Griggs","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Iowa State University College of Veterinary Medicine Ames Iowa 50011 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis","family":"Strong","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Iowa State University College of Veterinary Medicine Ames Iowa 50011 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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