{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T04:16:12Z","timestamp":1695528972929},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T00:00:00Z","timestamp":1483574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Case description<\/jats:title><jats:p>A 17\u2010year\u2010old female western lowland gorilla presented with bilateral ocular discharge, conjunctivitis, and rhinitis that was investigated and treated over a 34\u2010month period. Clinical findings, diagnostic results, treatment, and follow\u2010up are described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical finding<\/jats:title><jats:p>A mild intermittent mucoid ocular discharge was initially noted. 10 months later, conjunctival hyperemia and thickening developed and progressed rapidly to a mass\u2010like lesion covering the right eye. Hematology revealed eosinophilia. Conjunctival cytology revealed eosinophils and neutrophils, and histopathology revealed a chronic proliferative eosinophilic conjunctivitis. 21 months after, the ocular lesions were investigated the gorilla developed masses within both external nares. Histopathology of the nasal lesions revealed chronic\u2010active eosinophilic rhinitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Treatment and outcome<\/jats:title><jats:p>Treatment of the gorilla was based on protocols recommended for human patients. Protocols for mild, moderate, and finally severe disease were used, involving topical and oral combinations of treatments. The gorilla eventually responded to systemic immunosuppressant therapy recommended for severe refractory disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical significance<\/jats:title><jats:p>To the authors\u2019 knowledge, this is the first reported case of vernal\u2010like conjunctivitis in a western lowland gorilla.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12457","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T04:43:02Z","timestamp":1483677782000},"page":"199-204","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vernal\u2010like conjunctivitis in a western lowland gorilla (<i>Gorilla gorilla gorilla<\/i>)"],"prefix":"10.1111","volume":"21","author":[{"given":"Jane S.","family":"Hopper","sequence":"first","affiliation":[{"name":"Aspinall Foundation Port Lympne Wild Animal Park, Aldington Road Lympne Kent CT21 4PD UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Holding","sequence":"additional","affiliation":[{"name":"Aspinall Foundation Port Lympne Wild Animal Park, Aldington Road Lympne Kent CT21 4PD UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma J.","family":"Scurrell","sequence":"additional","affiliation":[{"name":"Cytopath Ltd PO Box 24 Ledbury Hertfordshire HR8 2YD UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Featherstone","sequence":"additional","affiliation":[{"name":"Willows Veterinary Centre and Referral service Highlands Road Shirley Solihull West Midlands B90 4NH UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,5]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2008.01347.x"},{"key":"e_1_2_4_3_1","first-page":"149","article-title":"Updates in the treatment of ocular allergies","volume":"3","author":"Kari O","year":"2010","journal-title":"Journal of Asthma and Allergy"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(00)00092-0"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700675"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2007.00568.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1638\/03-121.1"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1638\/03-010"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jmp.12114"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2011.00953.x"},{"key":"e_1_2_4_11_1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1128\/CMR.12.3.445","article-title":"Pathogenesis of onchocercal keratitis","volume":"12","author":"Hall L","year":"1999","journal-title":"Clinical Microbiology Reviews"},{"key":"e_1_2_4_12_1","volume-title":"Physiological Data Reference Values","author":"ISIS","year":"2013"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2009.10.011"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2005.00622.x"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2008.341"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.3129\/i06-061"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.95878"},{"key":"e_1_2_4_18_1","first-page":"88","article-title":"Ocular complications of vernal keratoconjunctivitis","volume":"34","author":"Tabbara K","year":"1999","journal-title":"Canadian Journal of Ophthalmology"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70271-5"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.1999.770505.x"},{"key":"e_1_2_4_21_1","first-page":"160","article-title":"Supratarsal injection of corticosteroids in the treatment of refractory vernal keratoconjunctivitis","volume":"50","author":"Singh S","year":"2002","journal-title":"Indian Journal of Ophthalmology"},{"key":"e_1_2_4_22_1","first-page":"19","article-title":"Supra\u2010tarsal injection of dexamethasone in the treatment of patients with refractory keratoconjunctivitis","volume":"41","author":"Lisanework M","year":"2003","journal-title":"Ethiopian Medical Journal"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.165548"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(86)90819-6"},{"key":"e_1_2_4_25_1","first-page":"644","article-title":"Treatment of severe vernal keratoconjunctivitis with cyclosporine A eye drops","volume":"20","author":"BenEzra D","year":"1988","journal-title":"Transplant Proceedings"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvop.12457","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvop.12457","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.12457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T05:12:07Z","timestamp":1695445927000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.12457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,5]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/vop.12457"],"URL":"https:\/\/doi.org\/10.1111\/vop.12457","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,5]]},"assertion":[{"value":"2017-01-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}