{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:26:08Z","timestamp":1788877568809,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether topical hypotensive medications prevent postoperative ocular hypertension (<jats:styled-content style=\"fixed-case\">POH<\/jats:styled-content>) after phacoemulsification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals studied<\/jats:title><jats:p>52 client\u2010owned dogs (88 eyes).<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>Diabetic and nondiabetic dogs having undergone phacoemulsification were included in this retrospective study. The control group received no ocular hypotensive medications. The treatment groups received latanoprost, dorzolamide, or dorzolamide\/timolol, beginning immediately after surgery, for 2\u2010week duration.<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>s were obtained at initial examination followed by 4 h, 24 h, 7 days, and 14 days postoperatively.<jats:styled-content style=\"fixed-case\">POH<\/jats:styled-content>was defined as an<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>above 20 mmHg (<jats:styled-content style=\"fixed-case\">POH<\/jats:styled-content>20) or 25 mmHg (<jats:styled-content style=\"fixed-case\">POH<\/jats:styled-content>25).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">POH<\/jats:styled-content>20 occurred in 33 of 87 eyes (37.93%), including 11 of 21 eyes (52.38%) in the control group, three of 23 eyes (13.04%) in the latanoprost group, eight of 15 eyes (53.33%) in the dorzolamide group, and 11 of 28 eyes (39.29%) in the dorzolamide\/timolol group. Active treatment groups were compared to the control group, and the overall group effect was not significant (<jats:italic>P<\/jats:italic>= 0.11).<jats:styled-content style=\"fixed-case\">POH<\/jats:styled-content>25 occurred in 22 of 86 eyes (25.58%), including seven of 21 eyes (33.33%) in the control group, two of 23 eyes (8.70%) in the latanoprost group, five of 15 eyes (33.33%) in the dorzolamide group, and eight of 27 eyes (29.63%) in the dorzolamide\/timolol group. Active treatment groups were compared to the control group, and the overall group effect was not significant (<jats:italic>P<\/jats:italic>= 0.31). Intraoperative use of intracameral tissue plasminogen activator significantly decreased the chances of<jats:styled-content style=\"fixed-case\">POH<\/jats:styled-content>25 (<jats:italic>P<\/jats:italic>= 0.0063).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical relevance<\/jats:title><jats:p>The latanoprost group had a substantially lower percentage of<jats:styled-content style=\"fixed-case\">POH<\/jats:styled-content>20 and<jats:styled-content style=\"fixed-case\">POH<\/jats:styled-content>25 compared to the control and other active treatment groups, although statistical significance was not achieved. Intraoperative intracameral tissue plasminogen activator decreased the incidence of<jats:styled-content style=\"fixed-case\">POH<\/jats:styled-content>25.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12461","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T08:42:42Z","timestamp":1486370562000},"page":"514-521","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effect of prophylactic topical hypotensive medications in reducing the incidence of postoperative ocular hypertension after phacoemulsification in dogs"],"prefix":"10.1111","volume":"20","author":[{"given":"D. Dustin","family":"Dees","sequence":"first","affiliation":[{"name":"Eye Care for Animals 12419 Metric Blvd Austin TX 78758 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate J.","family":"Spahn","sequence":"additional","affiliation":[{"name":"South Texas Veterinary Ophthalmology 503 E. 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