{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:55:04Z","timestamp":1792418104760,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T00:00:00Z","timestamp":1489708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To determine accuracy and precision of three commonly used tonometers (TonoVet\n                      <jats:sup>\u00ae<\/jats:sup>\n                      and TonoLab\n                      <jats:sup>\u00ae<\/jats:sup>\n                      (\n                      <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>\n                      are Oy, Finland)\u2014rebound tonometers, and Tono\u2010Pen\n                      <jats:styled-content style=\"fixed-case\">VET<\/jats:styled-content>\n                      \u2122 (Reichert,\n                      <jats:styled-content style=\"fixed-case\">NY<\/jats:styled-content>\n                      )\u2014applanation tonometer) in normal chinchillas, and to establish a normal intraocular pressure (\n                      <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\n                      ) reference range in this species.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The anterior chambers of three chinchilla eyes were cannulated\n                      <jats:italic>ex vivo<\/jats:italic>\n                      and readings obtained at manometric\n                      <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\n                      s from 5 to 80 mmHg, using each of the three tonometers in random order. Data were analyzed by linear regression,\n                      <jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content>\n                      , and Bland\u2013Altman plots. Tonometry was performed in both eyes of 60 chinchillas (age 8 weeks\u201316.2 years) using the TonoVet\n                      <jats:sup>\u00ae<\/jats:sup>\n                      and relationship between age and\n                      <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\n                      analyzed using linear regression. For all statistical tests,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05 was significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Intraocular pressure values obtained using the Tono\u2010Pen\n                      <jats:styled-content style=\"fixed-case\">VET<\/jats:styled-content>\n                      \u2122 and TonoVet\n                      <jats:sup>\u00ae<\/jats:sup>\n                      (in dog calibration mode;\u2018d\u2019) showed strong linear correlation with manometry within the physiologic and clinically relevant range of\n                      <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\n                      (0\u201350 mmHg). The TonoVet\n                      <jats:sup>\u00ae<\/jats:sup>\n                      \u2018d\u2019 setting displayed significantly greater precision over the full range of\n                      <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\n                      evaluated than the Tono\u2010Pen\n                      <jats:styled-content style=\"fixed-case\">VET<\/jats:styled-content>\n                      \u2122, and both TonoVet and Tono\u2010Pen\n                      <jats:styled-content style=\"fixed-case\">VET<\/jats:styled-content>\n                      \u2122 were significantly more accurate than the TonoLab\n                      <jats:sup>\u00ae<\/jats:sup>\n                      tonometer. Mean \u00b1\n                      <jats:styled-content style=\"fixed-case\">SD IOP<\/jats:styled-content>\n                      (TonoVet\n                      <jats:sup>\u00ae<\/jats:sup>\n                      \u2018d\u2019) in chinchillas was 9.7 \u00b1 2.5 mmHg, and the 95% reference interval was 4.7\u201314.7 mmHg.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Both the Tono\u2010Pen\n                      <jats:styled-content style=\"fixed-case\">VET<\/jats:styled-content>\n                      \u2122 and TonoVet\n                      <jats:sup>\u00ae<\/jats:sup>\n                      provided clinically acceptable estimates of\n                      <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\n                      in chinchillas. The TonoVet\n                      <jats:sup>\u00ae<\/jats:sup>\n                      provides accurate and precise\n                      <jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>\n                      values, while Tono\u2010Pen\n                      <jats:styled-content style=\"fixed-case\">VET<\/jats:styled-content>\n                      \u2122 derived measurements showed greater variability. Values obtained either with the TonoLab\n                      <jats:sup>\u00ae<\/jats:sup>\n                      or TonoVet\n                      <jats:sup>\u00ae<\/jats:sup>\n                      used in the \u2018unspecified\u2019 calibration setting were inaccurate in this species.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.12468","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T01:56:43Z","timestamp":1489715803000},"page":"4-9","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Tonometer validation and intraocular pressure reference values in the normal chinchilla (\n                    <i>Chinchilla lanigera)<\/i>"],"prefix":"10.1111","volume":"21","author":[{"given":"Kevin C.","family":"Snyder","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences School of Veterinary Medicine University of Wisconsin \u2013 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