{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:28:38Z","timestamp":1774326518275,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T00:00:00Z","timestamp":1499299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report 14 neoplasia\u2010free feline eyes enucleated for suspected intraocular neoplasia containing only iridociliary cysts. To analyze clinical findings that may have led veterinarians to suspect neoplasia in these globes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>The archives at the Comparative Ocular Pathology Laboratory of Wisconsin (<jats:styled-content style=\"fixed-case\">COPLOW<\/jats:styled-content>) were searched to identify neoplasia\u2010free feline globes enucleated for suspected neoplasia. Clinical data were obtained from medical records, veterinarian surveys, and<jats:styled-content style=\"fixed-case\">COPLOW<\/jats:styled-content>submission forms. All samples were examined grossly and histologically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All eyes were free of neoplasia and contained one or more iridociliary cysts. Nine of 14 globes were enucleated by or based on the recommendation of a board\u2010certified veterinary ophthalmologist. In eight of 14 cases, the submitting clinician listed melanoma as the only suspected diagnosis; in six of 14 cases, \u2018tumor\u2019 or \u2018mass\u2019 was listed. Clinical examination revealed a darkly pigmented intraocular mass in 11 of 14 cases. The mass was clinically perceived to be within the iris in seven of 14 cases. When examined histologically, 11 of 14 eyes contained multiple cysts, 13 of 14 contained multiloculated cysts, eight of 14 had a hyperplastic iris pigmented epithelium or cysts with thick black walls, and five of 14 had cysts prolapsed into the anterior chamber.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although most iridociliary cysts in cats are easily diagnosed on clinical examination, a subset may be mistaken for neoplasia. In cases of suspected iris melanoma, iridociliary cysts should be considered as a differential diagnosis, especially if a mass appears to emanate from behind the iris, dyscoria is present, or if similar changes are noted in the contralateral eye.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12484","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T11:51:40Z","timestamp":1499428300000},"page":"125-131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Iridociliary cysts masquerading as neoplasia in cats: a morphologic review of 14 cases"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9681-3748","authenticated-orcid":false,"given":"Jessica A.","family":"Fragola","sequence":"first","affiliation":[{"name":"Comparative Ocular Pathology Laboratory of Wisconsin Department of Pathobiological Sciences School of Veterinary Medicine University of Wisconsin\u2010Madison Madison WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard R.","family":"Dubielzig","sequence":"additional","affiliation":[{"name":"Comparative Ocular Pathology Laboratory of Wisconsin Department of Pathobiological Sciences School of Veterinary Medicine University of Wisconsin\u2010Madison Madison WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellison","family":"Bentley","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences School of Veterinary Medicine University of Wisconsin\u2010Madison Madison WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9960-678X","authenticated-orcid":false,"given":"Leandro B. C.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Comparative Ocular Pathology Laboratory of Wisconsin Department of Pathobiological Sciences School of Veterinary Medicine University of Wisconsin\u2010Madison Madison WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-2797-0.00009-6"},{"key":"e_1_2_5_3_1","first-page":"25","article-title":"Morphology and prognostic indicators of anterior uveal melanoma in cats","volume":"1","author":"Duncan DE","year":"1991","journal-title":"Progress in Veterinary Comparative Ophthalmology"},{"key":"e_1_2_5_4_1","first-page":"1477","volume-title":"Veterinary Ophthalmology","author":"Stiles J","year":"2013"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2460\/javma.1980.176.01.52","article-title":"Diffuse iris melanoma in cats","volume":"176","author":"Acland GM","year":"1980","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.1998.00006.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588802500201"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12344"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12345"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2004.04004.x"},{"key":"e_1_2_5_11_1","first-page":"3","volume-title":"Veterinary Ophthalmology","author":"Cook CS","year":"2013"},{"key":"e_1_2_5_12_1","first-page":"435","volume-title":"Veterinary Ophthalmology","author":"Grahn BH","year":"2013"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.76.6.540"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3129\/can j ophthalmol.i07-017"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.059535"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.223.1617"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvop.12484","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.12484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T14:28:03Z","timestamp":1750516083000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.12484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,6]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/vop.12484"],"URL":"https:\/\/doi.org\/10.1111\/vop.12484","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,6]]},"assertion":[{"value":"2017-07-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}