{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:58Z","timestamp":1787016058276,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T00:00:00Z","timestamp":1500249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The objectives of this retrospective study of 100 dogs with intraocular lymphoma were to describe the histomorphologic and immunohistochemical features of canine intraocular lymphoma, determine the proportion of cases with presumed solitary ocular lymphoma (\n                    <jats:styled-content style=\"fixed-case\">PSOL<\/jats:styled-content>\n                    ) compared to multicentric disease, and assess the clinical outcomes of these patients. Selected cases from Penn Vet Diagnostic Laboratory and Comparative Ocular Pathology Lab of Wisconsin (2004\u20132015) were evaluated and subtyped using the\n                    <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content>\n                    classification system. Peripheral T\u2010cell lymphoma and diffuse large B\u2010cell lymphoma were the two most common subtypes. Questionnaires were distributed to the referring veterinarians and veterinary ophthalmologists inquiring about clinical signs at time of enucleation, staging, patient outcome, treatment, and disease progression. Cases were categorized as\n                    <jats:styled-content style=\"fixed-case\">PSOL<\/jats:styled-content>\n                    if only ocular involvement was noted at the time of diagnosis based on the clinical staging criteria. The majority of cases (61%) did not have systemic involvement at the time of diagnosis, and these cases did not progress postoperatively. Median survival time (\n                    <jats:styled-content style=\"fixed-case\">MST<\/jats:styled-content>\n                    ) was significantly higher for the presumed solitary intraocular cases: 769 vs. 103\u00a0days, hazard ratio of 0.23 (95%\n                    <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                    : 0.077\u20130.68). The subtype of lymphoma did not affect survival time. The results of this study suggest two significant points of clinical interest: the majority of dogs (61%) presented without signs of systemic involvement of lymphoma at the time of enucleation, and dogs with only ocular involvement showed no disease progression postenucleation.\n                  <\/jats:p>","DOI":"10.1111\/vop.12492","type":"journal-article","created":{"date-parts":[[2017,7,17]],"date-time":"2017-07-17T01:32:36Z","timestamp":1500255156000},"page":"167-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Clinical and pathological classification of canine intraocular lymphoma"],"prefix":"10.1111","volume":"21","author":[{"given":"Matthew R.","family":"Lanza","sequence":"first","affiliation":[{"name":"Department of Pathobiology School of Veterinary Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayla R.","family":"Musciano","sequence":"additional","affiliation":[{"name":"Department of Pathobiology School of Veterinary Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Dubielzig","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences University of Madison\u2010Wisconsin Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy C.","family":"Durham","sequence":"additional","affiliation":[{"name":"Department of Pathobiology School of Veterinary Medicine University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,17]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"127","article-title":"Prevalence of ocular involvement in dogs with multicentric lymphoma prospective evaluation of 94 cases","volume":"4","author":"Krohne SG","year":"1994","journal-title":"Veterinary Comparative Ophthalmology"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985813478210"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1993.tb01021.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.244.4.460"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-36-5-404"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.2016.1152633"},{"key":"e_1_2_6_8_1","first-page":"1","article-title":"Intraocular and periocular lymphoma in dogs and cats: a retrospective review of 21 cases (2001\u20132012)","volume":"17","author":"Ota\u2010Kuroki J","year":"2013","journal-title":"Veterinary Ophthalmology"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810379428"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2010.04.027"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1988.10478612"},{"key":"e_1_2_6_12_1","unstructured":"ParkHM.Univariate analysis and normality test using SAS Stata and SPSS. Technical working paper. The University Information Technology Services (UITS) Center for Statistical and Mathematical Computing Indiana University. 2008."},{"key":"e_1_2_6_13_1","first-page":"1","article-title":"Canine and feline retinal lymphoma: a retrospective review of 12 cases","volume":"20","author":"Malmberg JL","year":"2016","journal-title":"Veterinary Ophthalmology"},{"key":"e_1_2_6_14_1","first-page":"92","article-title":"Principles of treatment for canine lymphoma","volume":"18","author":"Ettinger SN","year":"2003","journal-title":"Medical Oncology"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2003.10.009"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900020205"}],"container-title":["Veterinary Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvop.12492","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vop.12492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T01:11:01Z","timestamp":1695431461000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vop.12492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,17]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/vop.12492"],"URL":"https:\/\/doi.org\/10.1111\/vop.12492","archive":["Portico"],"relation":{},"ISSN":["1463-5216","1463-5224"],"issn-type":[{"value":"1463-5216","type":"print"},{"value":"1463-5224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,17]]},"assertion":[{"value":"2017-07-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}