{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T16:29:14Z","timestamp":1769099354666,"version":"3.49.0"},"reference-count":65,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:00:00Z","timestamp":1516320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate whether sedation with intramuscular butorphanol can interfere with different variables of the ocular examination in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals<\/jats:title><jats:p>Twenty\u2010two beagles without ophthalmic abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>Each dog was examined 20\u00a0min prior to and again just before administration of butorphanol to establish baseline data. The globe and nictitating membrane position was evaluated, and the following were recorded: menace response, dazzle reflex, corneal blink reflex, phenol red thread tear test (<jats:styled-content style=\"fixed-case\">PRT<\/jats:styled-content>), Schirmer tear test\u20101 (<jats:styled-content style=\"fixed-case\">STT<\/jats:styled-content>\u20101), pupil size (<jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>) measurement, and rebound tonometry. Then, butorphanol was injected intramuscularly at a dose of 0.2\u00a0mg\/kg and these procedures were repeated 10, 20, 30, and 45\u00a0min postadministration. A sedation score graded 0 to 3 was also established at these time points. Statistical analyses were performed on quantitative data using ANOVA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sedative effect was not associated with any changes in globe and nictitating membrane position; did not affect the results of the menace response, dazzle reflex, and corneal blink reflex; and had no significant effect on<jats:styled-content style=\"fixed-case\">PRT<\/jats:styled-content>values. However, butorphanol administration was associated with a statistically significant decrease in<jats:styled-content style=\"fixed-case\">STT<\/jats:styled-content>\u20101 and<jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>values (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.005), and a statistically significant increase in<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>(<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). All these variations remained in the range of normal values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>Butorphanol administered intramuscularly at 0.2\u00a0mg\/kg provided a degree of sedation allowing eye examination, but was found to interfere with<jats:styled-content style=\"fixed-case\">STT<\/jats:styled-content>\u20101,<jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>, and<jats:styled-content style=\"fixed-case\">IOP<\/jats:styled-content>values among the diagnostic tests studied. However, these values remained within normal limits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12530","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T13:31:24Z","timestamp":1516368684000},"page":"452-458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Effect of sedation with butorphanol on variables pertaining to the ophthalmic examination in dogs"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0426-4957","authenticated-orcid":false,"given":"Jean\u2010Yves","family":"Douet","sequence":"first","affiliation":[{"name":"D\u00e9partement des Sciences Cliniques Ecole Nationale V\u00e9t\u00e9rinaire de Toulouse Universit\u00e9 F\u00e9d\u00e9rale de Toulouse Midi\u2010Pyr\u00e9n\u00e9es 23 chemin des Capelles B.P. 87614 31076 Cedex 3 Toulouse 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