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Vascular changes were quantitatively evaluated by measuring peak intensity, time to initial upslope, and time to peak from the ciliary body, iris, choroid, retina, and the retrobulbar region by <jats:styled-content style=\"fixed-case\">CEUS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On <jats:styled-content style=\"fixed-case\">CEUS<\/jats:styled-content> images, all parts of the examined ocular structures were markedly enhanced and clearly identified from the adjacent region. After injection, the contrast agent initially flowed to the choroid and retina at 14.2\u00a0seconds, then to the ciliary body and iris at 20\u00a0seconds. The blood signal reached its peak intensity in the ciliary body at 27.2\u00a0seconds (47.4\u00a0\u00b1\u00a010.63), in the iris at 31.6\u00a0seconds (74.00\u00a0\u00b1\u00a041.85), and in the retrobulbar region at 23.4\u00a0seconds (149\u00a0\u00b1\u00a024.59). The optic nerve was clearly distinguished from the retrobulbar region over 5\u00a0minutes after the initiation of <jats:styled-content style=\"fixed-case\">CEUS<\/jats:styled-content>. Significantly, more vascular signals were detected in the ciliary body and iris by <jats:styled-content style=\"fixed-case\">CEUS<\/jats:styled-content> than by color and power Doppler.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Blood perfusion of the intraocular structures and the retrobulbar region can be quantitatively and qualitatively analyzed by <jats:styled-content style=\"fixed-case\">CEUS<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">CEUS<\/jats:styled-content> may be a useful, noninvasive, and sensitive tool for the evaluation of blood perfusion in ocular diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12562","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T10:36:54Z","timestamp":1520591814000},"page":"31-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Contrast\u2010enhanced ultrasonography for evaluation of 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