{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:58Z","timestamp":1787016058290,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To evaluate the use of hyaluronic acid (\n                      <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                      ) subdermal filler in canines and felines for entropion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Complete ophthalmologic examination was performed by a board\u2010certified veterinary ophthalmologist or\n                      <jats:styled-content style=\"fixed-case\">ABVO<\/jats:styled-content>\n                      \u2010approved resident. Each case was characterized as primary, secondary, spastic or cicatricial entropion.\n                      <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                      subdermal filler, specifically Restylane\n                      <jats:sup>\u00ae<\/jats:sup>\n                      and Restylane Silk\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , were utilized in dogs and cats, respectively. Subdermal injection was performed 1\u20102\u00a0mm from the eyelid margin in the affected area until normal eyelid conformation was achieved. All patients did not require sedation or general anesthesia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty animals (28 dogs and 12 cats) were included in the study. No local reaction to the\n                      <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                      dermal filler or any other complications other than minor skin bleeding at the injection sites were noted in all patients. Resolution of entropion and secondary complications including corneal ulceration, epiphora, and blepharospasm were noted by the first week after injection in the majority of cases. Three canines and one feline case failed to resolve the entropion, necessitating additional permanent surgical intervention. Two cases were submitted for histopathological analysis. Median follow\u2010up time for all cases was 152.5\u00a0days (mean: 194.6\u00a0\u00b1\u00a0142.7\u00a0days; range 9\u2010419\u00a0days). Five patients died or were euthanized during the study for unrelated causes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Hyaluronic acid (\n                      <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                      ) subdermal filler appears to be a safe, easy, reliable method for mild to moderate eyelid entropion not requiring general anesthesia. This procedure may be especially appropriate for geriatric patients and those with high anesthetic risk with entropion.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.12566","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T01:50:35Z","timestamp":1520560235000},"page":"105-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The use of hyaluronic acid subdermal filler for entropion in canines and felines: 40 cases"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0731-717X","authenticated-orcid":false,"given":"Jessica E.","family":"McDonald","sequence":"first","affiliation":[{"name":"Eye Care for Animals Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy M.","family":"Knollinger","sequence":"additional","affiliation":[{"name":"Eye Care for Animals Salt Lake City UT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,9]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"832","volume-title":"Veterinary Ophthalmology","author":"Stades FC","year":"2013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-3429-9.00005-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2007.00482.x"},{"key":"e_1_2_6_5_1","volume-title":"Slatter's Fundamentals of Veterinary Ophthalmology","author":"Maggs D","year":"2013"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2009.00705.x"},{"key":"e_1_2_6_7_1","first-page":"485","volume-title":"Feline Medicine and Surgery","author":"Roberts SR","year":"1975"},{"key":"e_1_2_6_8_1","first-page":"529","volume-title":"Veterinary Ophthalmology","author":"Nasisse MP","year":"1991"},{"key":"e_1_2_6_9_1","first-page":"155","article-title":"Palpebral fissure length in the dog and cat","volume":"2","author":"Stades FC","year":"1992","journal-title":"Prog Vet Comp Ophthalmol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.5326\/0420435"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-8478cr20141214"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12291"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.243.5.667"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctsap.2004.12.012"},{"key":"e_1_2_6_15_1","first-page":"38","article-title":"Feline entropion","volume":"10","author":"Weiss CW","year":"1980","journal-title":"Fel Prac"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2004.04050.x"},{"key":"e_1_2_6_17_1","first-page":"603","article-title":"A new method for surgical correction of upper eyelid trichiasis\u2010 entropion: operation method","volume":"23","author":"Stades FC","year":"1987","journal-title":"J Amer An Hosp Assoc"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2011.00974.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2004.04047.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12093"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2006.00243.x"},{"key":"e_1_2_6_22_1","first-page":"145","article-title":"Injectable collagen: a six\u2010year clinical investigation","volume":"9","author":"Cooperman L","year":"1985","journal-title":"J Internat Soc Plast Surg"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2006.20.151"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370520"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.02.064"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-5224.2002.00253.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118695920.ch2"},{"key":"e_1_2_6_28_1","first-page":"19","volume-title":"Injectable Fillers Principles and Practice","author":"Nowell Solish N","year":"2010"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820270903"},{"key":"e_1_2_6_30_1","unstructured":"Restylane\u00ae Products Website.Restylane\u00aeFamily of Products. 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