{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T23:01:43Z","timestamp":1774047703237,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T00:00:00Z","timestamp":1540512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze a study population of dogs with primary corneal endothelial degeneration (<jats:styled-content style=\"fixed-case\">PCED<\/jats:styled-content>) for information on the patterns of disease and to report the efficacy of superficial keratectomy (<jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>) for resolution of non\u2010healing corneal ulcers associated with <jats:styled-content style=\"fixed-case\">PCED<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animals studied<\/jats:title><jats:p>Primary corneal endothelial degeneration was diagnosed in 238 dogs between 1998 and 2017. Corneal ulceration associated with <jats:styled-content style=\"fixed-case\">PCED<\/jats:styled-content> was present in 89 dogs (109 eyes), of which 47 eyes were treated with <jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>A retrospective assessment of medical records was performed to determine the signalment patterns of <jats:styled-content style=\"fixed-case\">PCED<\/jats:styled-content>, and the success rate of the <jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content> procedure for resolving <jats:styled-content style=\"fixed-case\">PCED<\/jats:styled-content>\u2010associated corneal ulceration. Descriptive statistics were reported on the signalment of <jats:styled-content style=\"fixed-case\">PCED<\/jats:styled-content> cases, with odd ratios and confidence intervals calculated to detect breed predispositions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Primary corneal endothelial degeneration was diagnosed in 238 dogs, 40.8% were female and 59.2% were male, with a mean age at diagnosis of 11.4\u00a0years. Dachshunds, Dalmatians, English Springer Spaniels, Welsh Springer Spaniels, Chihuahuas, Cocker Spaniels, and Golden Retrievers were significantly over\u2010represented. All <jats:styled-content style=\"fixed-case\">PCED<\/jats:styled-content>\u2010affected Dalmatians developed associated corneal ulceration. Follow\u2010up information was available for 41\/47 eyes treated with <jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>. At the first reassessment, 87.8% were healed which increased to 97.6% with subsequent monitoring. Four eyes (9.8%) had late corneal ulcer occurrence following <jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>, at a median time following <jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content> of 182\u00a0weeks post\u2010surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Superficial keratectomy was an effective option for resolving painful non\u2010healing corneal ulcers associated with <jats:styled-content style=\"fixed-case\">PCED<\/jats:styled-content>. Dalmatians may be at increased risk of developing <jats:styled-content style=\"fixed-case\">PCED<\/jats:styled-content>\u2010associated corneal ulceration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12617","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T12:39:13Z","timestamp":1540557553000},"page":"485-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Superficial keratectomy as a treatment for non\u2010healing corneal ulceration associated with primary corneal endothelial degeneration"],"prefix":"10.1111","volume":"22","author":[{"given":"Kellam D.","family":"Bayley","sequence":"first","affiliation":[{"name":"Veterinary Ophthalmic Referrals Plympton, Adelaide SA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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