{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:04:25Z","timestamp":1792004665285,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T00:00:00Z","timestamp":1549238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007807","name":"Japan Science Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We investigated the early posttreatment effects of two steroidal anti\u2010inflammatory ophthalmic drugs on blood\u2010aqueous barrier (BAB) breakdown by paracentesis in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Animal studies<\/jats:title><jats:p>We studied 21 healthy beagles with normal eyes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedures<\/jats:title><jats:p>Controlled anterior chamber paracentesis (0.5\u00a0mL) was performed in one eye of each dog. Control group dogs (n\u00a0=\u00a07) received no medication, whereas those in the treatment groups received a topical anti\u2010inflammatory medication (difluprednate [DFBA] ophthalmic emulsion 0.05% [n\u00a0=\u00a07] or betamethasone [BMZ] sodium phosphate ophthalmic solution 0.1% [n\u00a0=\u00a07]) at 0, 15, 30, and 45\u00a0minutes after initial paracentesis in the paracentesed eyes. Secondary aqueous humor (AH) was collected 60\u00a0minutes after initial paracentesis. Protein and prostaglandin E<jats:sub>2<\/jats:sub>(PGE<jats:sub>2<\/jats:sub>) concentrations in AH were determined using the bicinchoninic acid assay and commercially available immunoassay kit, respectively. All mean values in the three groups were compared using analysis of variance followed by Tukey's post hoc test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Aqueous protein and PGE<jats:sub>2<\/jats:sub>concentrations were markedly increased at 60\u00a0minutes following paracentesis. Both concentrations in the secondary AH of the DFBA group were significantly lower than those of the control group; however, treatment with BMZ had no significant effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early postparacentesis treatment with DFBA was more effective than that with BMZ for reducing aqueous protein and PGE<jats:sub>2<\/jats:sub>contents in dogs with paracentesis\u2010induced BAB breakdown. DFBA may be an appropriate treatment during the early stage of anterior uveitis caused by intraocular surgery in dogs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12629","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T09:27:55Z","timestamp":1549358875000},"page":"607-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of early posttreatment effects of two steroidal anti\u2010inflammatory ophthalmic drugs on the ocular inflammatory response induced by paracentesis in healthy canine eyes"],"prefix":"10.1111","volume":"22","author":[{"given":"Kazuaki","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Small Animal Internal Medicine II, School of Veterinary Medicine Kitasato University Towada, Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiwako","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Small Animal Internal Medicine II, School of Veterinary Medicine Kitasato University Towada, Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Nagai","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Kindai University Higashi\u2010Osaka, Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Small Animal Internal Medicine II, School of Veterinary Medicine Kitasato University Towada, Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seishiro","family":"Chikazawa","sequence":"additional","affiliation":[{"name":"Department of Small Animal Internal Medicine II, School of Veterinary Medicine Kitasato University Towada, Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Department of Small Animal Internal Medicine II, School of Veterinary Medicine Kitasato University Towada, Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutaka","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Small Animal Internal Medicine II, School of Veterinary Medicine Kitasato University Towada, Aomori Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701349"},{"key":"e_1_2_7_3_1","first-page":"1119","article-title":"Disorder of blood\u2010aqueous barrier following Ahmed Glaucoma Valve implantation","volume":"126","author":"Zhou MW","year":"2013","journal-title":"Chinese Medical Journal (English Edition)"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2011.290"},{"key":"e_1_2_7_5_1","first-page":"33","article-title":"Morphology of the breakdown of the blood\u2010aqueous barrier in the ciliary processes of the rabbit eye after prostaglandin E2","volume":"14","author":"Vegge T","year":"1975","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1965.sp007557"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/newbio239248a0"},{"key":"e_1_2_7_8_1","first-page":"572","article-title":"Effect of aspirin on aqueous protein values in the dog","volume":"178","author":"Brightman AH","year":"1981","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfo.2014.10.014"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2011.00876.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)31923-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"875","DOI":"10.2460\/ajvr.1996.57.06.875","article-title":"Comparative efficacy of topically applied flurbiprofen, diclofenac, tolmetin, and suprofen for the treatment of experimentally induced blood\u2010aqueous barrier disruption in dogs","volume":"57","author":"Ward DA","year":"1996","journal-title":"Am J Vet Res"},{"key":"e_1_2_7_13_1","first-page":"117","article-title":"Comparison of the blood\u2010aqueous barrier stabilizing effects of steroidal and nonsteroidal anti\u2010inflammatory agents in the dog","volume":"3","author":"Ward DA","year":"1992","journal-title":"Progress in Veterinary & Comparative Ophthalmology"},{"key":"e_1_2_7_14_1","unstructured":"StrongTD WehrmanRF Ben\u2010ShlomoG et al.Comparison of topical 1% prednisolone acetate to 0.05% difluprednate in inhibiting paracentesis\u2010induced blood aqueous barrier breakdown in dogs. 47th Annual Meeting of the American College of Veterinary Ophthalmologists (ACVO). 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