{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:04:53Z","timestamp":1788199493297,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009944","name":"ACVO Vision for Animals Foundation","doi-asserted-by":"publisher","award":["2016-0459\/VAFSARDS2015"],"award-info":[{"award-number":["2016-0459\/VAFSARDS2015"]}],"id":[{"id":"10.13039\/100009944","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify discriminating factors, using clinical ophthalmic examination findings and routine laboratory testing, that differentiate dogs with early sudden acquired retinal degeneration (SARDS; vision loss &lt;6\u00a0weeks\u2019 duration), age\u2010 and breed\u2010matched control dogs, and dogs with pituitary\u2010dependent hyperadrenocorticism (PDH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Client\u2010owned dogs: 15 with SARDS with &lt;6\u00a0weeks duration of vision loss, 14 age\u2010 and breed\u2010matched control dogs, and 13 dogs with confirmed PDH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedures<\/jats:title>\n                    <jats:p>Dogs underwent ophthalmic examination, electroretinography (ERG) fundus photography, and spectral\u2010domain optical coherence tomography (SD\u2010OCT) in addition to physical examination, urinalysis, serum biochemistry, complete blood count, and adrenocorticotrophic hormone (ACTH) stimulation testing. Statistical analysis was performed using receiver operating curve area under the curve analysis, principal component analysis with sparse partial least squares analysis, and one\u2010way ANOVA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Dogs with SARDS all had absent vision and ERG a\u2010 and b\u2010waves. SD\u2010OCT demonstrated that dogs with SARDS had significantly thicker inner retina, thinner outer nuclear layer, and thicker photoreceptor inner\/outer segment measurements than either controls or dogs with PDH. Discriminating laboratory parameters between dogs with SARDS and PDH with high specificity included post\u2010ACTH serum cortisol (&lt;19.3\u00a0\u03bcg\/dL), AST:ALT ratio (&gt;0.343), and urine specific gravity (&gt;1.030).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Relevance<\/jats:title>\n                    <jats:p>We have identified significant discriminators between SARDS and PDH. This work provides the basis for future studies that could identify and examine dogs with SARDS prior to vision loss, which may extend the potential therapeutic window for SARDS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vop.12661","type":"journal-article","created":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T02:33:59Z","timestamp":1552444439000},"page":"842-858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Diagnostic utility of clinical and laboratory test parameters for differentiating between sudden acquired retinal degeneration syndrome and pituitary\u2010dependent hyperadrenocorticism in dogs"],"prefix":"10.1111","volume":"22","author":[{"given":"Annie","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6392-7418","authenticated-orcid":false,"given":"Melanie L.","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan G.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaowen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Statistics North Carolina State University Raleigh North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Ru","sequence":"additional","affiliation":[{"name":"Department of Population Health and Pathobiology, College of Veterinary Medicine North Carolina State University Raleigh North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7083-5861","authenticated-orcid":false,"given":"Katharine F.","family":"Lunn","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8726-8768","authenticated-orcid":false,"given":"Freya M.","family":"Mowat","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12291"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.5326\/0450207"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.243.10.1426"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12370"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-5224.2008.00652.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12504"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12602"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12597"},{"key":"e_1_2_6_10_1","unstructured":"AclandGM IrbyNL AguirreGD GrossS NitroySF NotarfrancescoK.Sudden acquired retinal degeneration in the dog: clinical and morphologic characterization of the \u201csilent retina\u201d syndrome (abstract). 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