{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:28:56Z","timestamp":1779312536473,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T00:00:00Z","timestamp":1558051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Applied Veterinary Research","award":["DE. 120470.2.39"],"award-info":[{"award-number":["DE. 120470.2.39"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Veterinary Ophthalmology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effects of topical dorzolamide 2% q8h and brinzolamide 1% q8h, administered either alone (A and B, respectively) or in combination with topical timolol 0.5% q12h (C and D, respectively), on the circadian pattern of intraocular pressure (IOP), the pupil size, and heart rate in healthy cats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective, randomized, double\u2010blinded study, 10 healthy, adult cats were randomly assigned to one of four groups and the eye to be medicated was randomly assigned. IOP, pupil diameter, and heart rate were measured at 3\u2010hour intervals. A 5\u00a0days\u2019 adjustment period was followed by a 5\u00a0days\u2019 placebo (baseline) period. Then, all groups of cats received all four treatments (A\u2010D) according to a Latin square\u2010based rotating schedule. Five days\u2019 medication periods were alternated with 3\u00a0days\u2019 washout periods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean baseline IOP was 13.6\u00a0\u00b1\u00a02.7\u00a0mm\u00a0Hg. All treatments resulted in a statistically significant decrease in mean IOP in the treated eye: A: \u22122.33\u00a0mm\u00a0Hg (95% CI: \u22122.71, \u22121.94), B: \u22121.91\u00a0mm\u00a0Hg (95% CI: \u22122.30, \u22121.53), C: \u22122.36\u00a0mm\u00a0Hg (95% CI: \u22122.74, \u22121.97), and D: \u22122.37\u00a0mm\u00a0Hg (95% CI: \u22122.76, \u22121.98) and the nontreated eye: A: \u22120.19\u00a0mm\u00a0Hg (95% CI: \u22120.28, \u22120.11), B: \u22120.18\u00a0mm\u00a0Hg (95% CI: \u22120.27, \u22120.10), C \u22120.31\u00a0mm\u00a0Hg (95% CI: \u22120.40, \u22120.23), and D: \u22120.24\u00a0mm\u00a0Hg (95% CI: \u22120.32, \u22120.15). Timolol resulted in an additional, significant decrease in IOP of 4% and 5%, respectively, compared to A and B, and in mild bradycardia and miosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Topical administration of dorzolamide 2% and brinzolamide 1% q8h significantly decreased IOP in healthy cats. Supplemental timolol 0.5% eye drops q12h resulted in an additional, statistically significant reduction of IOP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vop.12679","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T09:35:53Z","timestamp":1558085753000},"page":"16-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The effects of topical dorzolamide 2% and brinzolamide 1%, either alone or combined with timolol 0.5%, on intraocular pressure, pupil diameter, and heart rate in healthy cats"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4061-6542","authenticated-orcid":false,"given":"Inge J. 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